Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates

Lawrence C. Creemer; Douglas E. Kiehl

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Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates

机译：替米考星和泰乐菌素相关半抗原的轻松合成，用作蛋白质缀合物

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Synthesis is described for the haptens 23-demycinosyl-23-deoxy-23-(3-aminoprop-1-yl)-aminotilmicosin (6) from 5-O-mycaminosyltylonolide (OMT) and for 23-demycinosyl-23-deoxy-23-(3-aminoprop-1-yl)-amino-20-dihydrotylosin (10) from demycinosyltylosin (DMT), respectively. The mild reaction conditions used to synthesize the second hapten, DMT derivative 10, were necessary to overcome instabilities and acid lability of DMT. The haptens synthesized here may be further used to produce protein conjugates useful in developing antibodies against the antibiotics tilmicosin and tylosin.

机译：描述了从5-O-mycaminosyltylonolide（OMT）合成半抗原23-demycinosyl-23-deoxy-23-（3-aminoprop-1-yl）-aminotilmicosin（6）和23-demycinosyl-23-deoxy-23的合成方法。分别由脱霉素糖基酪蛋白（DMT）制得的-（3-氨基丙-1-基）-氨基-20-二氢酪蛋白（10）。用于合成第二种半抗原DMT衍生物10的温和反应条件是克服DMT的不稳定性和酸稳定性所必需的。此处合成的半抗原可进一步用于产生蛋白偶联物，可用于开发针对抗生素替米考星和泰乐菌素的抗体。

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《The Journal of Antibiotics: An International Journal》 |2003年第5期|共7页
作者
Lawrence C. Creemer; Douglas E. Kiehl;
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正文语种 eng
中图分类药学;
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1. Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates [J] . Lawrence C. Creemer, Douglas E. Kiehl The Journal of Antibiotics: An International Journal . 2003,第5期

机译：替米考星和泰乐菌素相关半抗原的轻松合成，用作蛋白质缀合物
2. Simultaneous detection of tylosin and tilmicosin in honey using a novel immunoassay and immunochromatographic strip based on an innovative hapten [J] . Song Yuehong, Song Shanshan, Liu Liqiang, Food and Agricultural Immunology . 2016,第3a4期

机译：基于新型半抗原的新型免疫测定和免疫层析试纸同时检测蜂蜜中的泰乐菌素和替米考星
3. Simultaneous detection of tylosin and tilmicosin in honey using a novel immunoassay and immunochromatographic strip based on an innovative hapten [J] . Yuehong Song, Shanshan Song, Liqiang Liu, Food and Agricultural Immunology . 2016,第3期

机译：基于新型半抗原的新型免疫测定和免疫层析试纸同时检测蜂蜜中的泰乐菌素和替米考星
4. Synthesis and identification of the ciprofioxacin hapten-protein Conjugates [C] . Xuan-yun HUANG, Dong-mei HUANG, Yong-fu SHI International Conference on Chemical Engineering and Advanced Materials . 2013

机译：CiProfioxacin Hapten-蛋白缀合物的合成和鉴定
5. Part I. A small-molecule library strategy for disruption of protein-protein interactions. Part II. Antibody-catalyzed anaerobic destruction of methamphetamine: A new direction in immunopharmacotherapy. Part III. Design and synthesis of reactive immunization haptens. [D] . Xu, Yang. 2007

机译：第一部分。破坏蛋白质间相互作用的小分子文库策略。第二部分甲基苯丙胺的抗体催化厌氧破坏：免疫药物治疗的新方向。第三部分反应性免疫半抗原的设计与合成。
6. Design of Novel Haptens and Development of Monoclonal Antibody-Based Immunoassays for the Simultaneous Detection of Tylosin and Tilmicosin in Milk and Water Samples [O] . Jian-Xin Huang, Chan-Yuan Yao, Jin-Yi Yang, 2019

机译：同时检测牛奶和水样中泰乐菌素和Tilmicosin的新型半抗原的设计和基于单克隆抗体的免疫分析方法的发展
7. Design of Novel Haptens and Development of Monoclonal Antibody-Based Immunoassays for the Simultaneous Detection of Tylosin and Tilmicosin in Milk and Water Samples [O] . Jian-Xin Huang, Chan-Yuan Yao, Jin-Yi Yang, 2019

机译：新型举例设计的设计与单克隆抗体基免疫测定的开发，同时检测牛奶和水样中的替辛和蒂米霉素

Facile Synthesis of Tilmicosin and Tylosin Related Haptens for Use as Protein Conjugates

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