Studies on novel bacterial translocase I inhibitors, A-500359s I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation of A-500359 A, C, D and G

Yasunori Muramatsu; Akiko Muramatsu; Takashi Ohnuki; Michiko Miyazawa Ishii; Masaaki Kizuka; Ryuzo Enolita; Shinya Tsutsumi; Masatoshi Arai; Yasumasa Ogawa; Toshihiro Suzuki; Toshio Takatsu; Masatoshi Inukai

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Studies on novel bacterial translocase I inhibitors, A-500359s I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation of A-500359 A, C, D and G

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Studies on novel bacterial translocase I inhibitors, A-500359s I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation of A-500359 A, C, D and G

机译：新型细菌转运酶I抑制剂A-500359s的研究I. A-500359 A，C，D和G的分类，发酵，分离，理化性质和结构解析

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In the course of our screening for bacterial phospho-N-acetylmuramyl-pentapeptide-translocase 9translocase I: EC 2.7.8.13) inhibitors, we found inhibitoryy activity in the culture broth of the strain identified as Streptomyces griseus SANK 60196. The strain produced capuramycin and four novel capuramycin derivatives designated as A-500359 A, C, D and G. Purification and structural analysis were performed, and the structures of A-500359 A, C, D and G were elucidated as 6"'-methylcapuramycin, 3'-demethyl-6"'-methylcapuramycin, 2"-deoxy-6"'-methylcapuramycin and 3'-demethylcapuramycin, respectively.

机译：在筛选细菌性磷酸-N-乙酰基村酰基五肽-转座酶9（转座酶I：EC 2.7.8.13）抑制剂的过程中，我们发现了该菌株的培养液中的抑制活性，该菌株被鉴定为灰链霉菌SANK60196。该菌株产生了卡普拉霉素和四种新的卡普拉霉素衍生物分别命名为A-500359 A，C，D和G。进行了纯化和结构分析，并将A-500359 A，C，D和G的结构阐明为6“'-甲基卡普拉霉素，3'-脱甲基-6”'-甲基capuramycin，2”-脱氧-6”'-甲基capuramycin和3'-demethylcapuramycin。

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《The Journal of Antibiotics: An International Journal》 |2003年第3期|共10页
作者
Yasunori Muramatsu; Akiko Muramatsu; Takashi Ohnuki; Michiko Miyazawa Ishii; Masaaki Kizuka; Ryuzo Enolita; Shinya Tsutsumi; Masatoshi Arai; Yasumasa Ogawa; Toshihiro Suzuki; Toshio Takatsu; Masatoshi Inukai;
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正文语种 eng
中图分类药学;药品;
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机译：新型细菌转运酶I抑制剂A-500359s的研究I. A-500359 A，C，D和G的分类，发酵，分离，理化性质和结构解析
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Studies on novel bacterial translocase I inhibitors, A-500359s I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation of A-500359 A, C, D and G

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