PTERULINIC ACID AND PTERULONE, TWO NOVEL INHIBITORS OF NADH-UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PRODUCED BY A PTERULA SPECIES .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

Engler M.; Sterner O.; Anke T.

首页> 外文期刊>The Journal of Antibiotics: An International Journal >PTERULINIC ACID AND PTERULONE, TWO NOVEL INHIBITORS OF NADH-UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PRODUCED BY A PTERULA SPECIES .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

【24h】

PTERULINIC ACID AND PTERULONE, TWO NOVEL INHIBITORS OF NADH-UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PRODUCED BY A PTERULA SPECIES .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

机译：蝶孢菌种产生的NADH-泛醌氧化还原酶（化合物I）的两种新型抑制剂：蝶呤酸和蝶呤.2。物理化学性质和结构腐蚀

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The structures of two novel fungal antibiotics, isolated from a Pterula species, that interfere with the NADH:ubiquinone oxidoreductase and inhibit the respiration of eucaryotes, were determined by spectroscopic techniques. Both compounds, pterulinic acid (1a) and pterulone (2), contain a 1-benzoxepin ring system and are chlorinated. Pterulinic acid (1a), which was obtained as a 1:5 inseparable mixture of the two isomers (Z)-1a and (E)-1a, in addition contains a furan. Their structures were determined by mass spectrometry and NMR spectroscopy, and 2D heteronuclear correlation experiments permitted the assignment of all NMR signals. [References: 5]

机译：通过光谱技术确定了两种分离自翼藻的新型真菌抗生素的结构，它们干扰了NADH：泛醌氧化还原酶并抑制了真核生物的呼吸。两种化合物，蝶酸（1a）和蝶酮（2）均含有一个1-苯并二环系统，并已被氯化。以两种异构体（Z）-1a和（E）-1a的1：5不可分离的混合物形式获得的蝶酸（1a）还含有呋喃。它们的结构通过质谱和NMR光谱确定，并且2D异核相关实验允许分配所有NMR信号。 [参考：5]

著录项

来源
《The Journal of Antibiotics: An International Journal》 |1997年第4期|共4页
作者
Engler M.; Sterner O.; Anke T.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;药品;
关键词

相似文献

外文文献
专利

1. PTERULINIC ACID AND PTERULONE, TWO NOVEL INHIBITORS OF NADH-UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PRODUCED BY A PTERULA SPECIES .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION [J] . Engler M., Sterner O., Anke T. The Journal of Antibiotics: An International Journal . 1997,第4期

机译：蝶孢菌种产生的NADH-泛醌氧化还原酶（化合物I）的两种新型抑制剂：蝶呤酸和蝶呤.2。物理化学性质和结构腐蚀
2. MR566A AND MR566B, NEW MELANIN SYNTHESIS INHIBITORS PRODUCED BY TRICHODERMA HARZIANUM .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURAL ELUCIDATION [J] . Lee CH., Chung MC., Lee HJ., The Journal of Antibiotics: An International Journal . 1997,第6期

机译：哈氏毛滴虫生产的新型黑色素合成抑制剂MR566A和MR566B.2。物理化学性质和结构电沉积
3. PF1092A, B AND C, NEW NONSTEROIDAL PROGESTERONE RECEPTOR LIGANDS PRODUCED BY PENICILLIUM OBLATUM .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION [J] . Tabata Y., Kurata Y., Miyajima K., The Journal of Antibiotics: An International Journal . 1997,第4期

机译：由青霉菌产生的新的非甾体孕酮受体PF1092A，B和C.2。物理化学性质和结构腐蚀
4. Synthesis and Inhibitory Action of Novel Acetogenin Mimics Alac-Acetogenins: A New Class of Inhibitors of Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex-I) [C] . Hideto Miyoshi, Naoya Ichimaru, Masatoshi Murai IUPAC International Congress of Pesticide Chemistry . 2007

机译：新型丙酮糖素模拟物的合成及抑制作用Alac-acetogens：一种新的线粒体Nadh-ubiquinone氧化还原酶抑制剂（复合物-I）
5. Part 1. Structure, stability and reactivity of small organic sulfinic and sulfonic acids: Toxicological implications. Part 2. Role of charge transfer complexes in oxidative cleavage of benzpinacols by iron(III) trisphenanthroline [D] . Svarovsky, Serge Alex 2000

机译：第1部分。小的有机亚磺酸和磺酸的结构，稳定性和反应性：毒理学意义。第2部分。电荷转移配合物在三苯菲啉铁（III）氧化裂解苯并萘类中的作用
6. Synthesis and Characterization of New Piperazine-Type Inhibitors for Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) [O] . Naoya Ichimaru, Masatoshi Murai, Nobuyuki Kakutani, -1

机译：线粒体NADH-泛醌氧化还原酶的新型哌嗪类抑制剂的合成与表征（化合物I）
7. Pterulinic Acid and Pterulone, Two Novel Inhibitors of NADH: Ubiquinone Oxidoreductase (Complex I) Produced by a Pterla Species. II. Physico-chemical Properties and Structure Elucidationt. [O] . MICHAELA ENGLER, TIMM ANKE, OLOV STERNER 1997

机译：翼状素酸和椎体，两种新抑制剂的NADH：由Pterla物种产生的泛醌氧化酶（络合物I）。 II。物理化学性质和结构阐明。
8. The Interaction of Hydrazine with Copper(II) Chloride in Acidic Solutions. The Formation, Spectral and Magnetic Properties, and Structures of Copper(II), Copper(I), and Mixed Valence Species. [R] . Brown, D. B., Donner, J. A., Hall, J. W., 1979

机译：肼与氯化铜（II）在酸性溶液中的相互作用。铜（II），铜（I）和混合价物种的形成，光谱和磁性以及结构。

PTERULINIC ACID AND PTERULONE, TWO NOVEL INHIBITORS OF NADH-UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PRODUCED BY A PTERULA SPECIES .2. PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE ELUCIDATION

摘要

著录项

相似文献

相关主题

期刊订阅