S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans - I. Producing strain, fermentation, isolation and biological activity

Sato T.; Arioka M.; Ando K.; Sugiyama J.; Uramoto M.; Yamasaki M.; Kitamoto K.; Hanada T.

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S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans - I. Producing strain, fermentation, isolation and biological activity

机译：S19159，一种由子囊虫普雷氏菌产生的神经突增生调节剂-I.产生菌株，发酵，分离和生物学活性

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A modulator of neurite outgrowth, designated S19159, was isolated from the fermentation broth of fungal strain 19159. This fungus was identified as the loculoascomycete, Preussia aemulans (Rehm) von Arx. In the presence of S19159, the number of neurites extending from the cell bodies of cerebral cortical neurons was markedly reduced. The effect of S19159 was observed specifically in neurons from the central nervous system. The compound exhibited similar activities on cultured cortical, hippocampal and cerebeller neurons but was without detectable effect on dorsal root ganglion neurons and PC12 cells. [References: 8]

机译：从真菌菌株19159的发酵液中分离出了神经突增生调节剂，命名为S19159。该真菌被鉴定为小孢子囊菌，普雷氏菌（Reus）von Arx。在存在S19159的情况下，从大脑皮层神经元细胞体延伸出的神经突数量明显减少。专门在中枢神经系统的神经元中观察到了S19159的作用。该化合物对培养的皮质，海马和小脑神经元表现出相似的活性，但对背根神经节神经元和PC12细胞没有可检测的作用。 [参考：8]

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《The Journal of Antibiotics: An International Journal》 |1998年第10期|共5页
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Sato T.; Arioka M.; Ando K.; Sugiyama J.; Uramoto M.; Yamasaki M.; Kitamoto K.; Hanada T.;
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正文语种 eng
中图分类药学;药品;
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1. S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans - I. Producing strain, fermentation, isolation and biological activity [J] . Sato T., Arioka M., Ando K., The Journal of Antibiotics: An International Journal . 1998,第10期

机译：S19159，一种由子囊虫普雷氏菌产生的神经突增生调节剂-I.产生菌株，发酵，分离和生物学活性
2. PF1163A and B, new antifungal antibiotics produced by Penicillium sp I. Taxonomy of producing strain, fermentation, isolation and biological activities [J] . Nose H., Yaguchi T., Hosoya A., The Journal of Antibiotics: An International Journal . 2000,第1期

机译：PF1163A和B，由青霉属I生产的新型抗真菌抗生素。产生菌株，发酵，分离和生物学活性的分类
3. SB-253514 and Analogues; Novel Inhibitors of Lipoprotein-Associated Phospholipase A_2 Produced by Pseudomonas fluorescens DSM 11579 I. Fermentation of Producing Strain, Isolation and Biological Activity [J] . THIRKETTLE JAN The Journal of Antibiotics: An International Journal . 2000,第7期

机译：SB-253514和类似物;荧光假单胞菌DSM 11579产生的脂蛋白相关磷脂酶A_2的新型抑制剂I.发酵菌株的生产，分离和生物学活性
4. Isolation and Identification of an Inulinase-Producing Strain and the Optimization of Its Fermentation Condition [C] . Yang Zhang, Hongyang Zhu, Jinhai Wang, International conference on applied biotechnology . 2015

机译：菊粉酶生产菌的分离鉴定及其发酵条件的优化
5. The isolation of ocean microbes that produce antibiotics against Pseudomonas aeruginosa strains from cystic fibrosis patients [D] . Walsh, Dennis M. 2018

机译：从囊性纤维化患者中分离出产生针对铜绿假单胞菌菌株的抗生素的海洋微生物
6. Fermentation Isolation Structure and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667 [O] . Asha A Kulkarni-Almeida, Manoja K Brahma, Prabhu Padmanabhan, 2011

机译：链霉菌PM0324667菌株产生的NFAT-133的发酵分离结构及抗糖尿病活性
7. S19159, a Modulator of Neurite Outgrowth Produced by the Ascomycete Preussia aemulans. II. Structure Elucidation. [O] . TAKAAKI SATO, TOSHIHIKO HANADA, MANABU ARIOKA, 1998

机译：S19159是由Ascomycete Preussia Aemulans产生的神经肌腱过谱的调节剂。 II。结构阐明。

S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans - I. Producing strain, fermentation, isolation and biological activity

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