New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.

Matsuda D; Namatame I; Tomoda H; Kobayashi S; Zocher R; Kleinkauf H; Omura S

首页> 外文期刊>The Journal of Antibiotics: An International Journal >New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.

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New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.

机译：氨基酸补充白僵菌发酵产生的新的甜菜碱。 FO-6979。

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Five new beauveriolides were isolated from the acetone extracts of Beauveria sp. FO-6979 mycelia fermented in amino acid-supplemented media. The structures were elucidated by spectroscopic studies including NMR experiments and chemical degradation. All the beauveriolides are cyclodepsipeptides consisting of one 3-hydroxy-4-methyl fatty acid, two L-amino acids and one D-amino acid in common. Beauveriolide VII with the structure of cyclo-[3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl-D-valyl] inhibited lipid droplet formation and cholesteryl ester synthesis in macrophages, but the other beauveriolides showed only slight or almost no effect on lipid droplet formation.

机译：从球孢白僵菌的丙酮提取物中分离出五个新的甜菜碱内酯。 FO-6979菌丝体在添加氨基酸的培养基中发酵。通过包括NMR实验和化学降解在内的光谱研究阐明了结构。所有的甜菜碱内酯都是环二肽，由共同的一种3-羟基-4-甲基脂肪酸，两种L-氨基酸和一种D-氨基酸组成。具有环-[3-羟基-4-甲基辛酰基-L-苯丙氨酰基-L-丙氨酰基-D-戊酰基]结构的白藜芦醇VII抑制巨噬细胞中脂质滴的形成和胆固醇酯的合成，但是其他的古丁苯胺化物仅显示很少或几乎没有对脂质液滴形成的影响。

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来源
《The Journal of Antibiotics: An International Journal》 |2004年第1期|共9页
作者
Matsuda D; Namatame I; Tomoda H; Kobayashi S; Zocher R; Kleinkauf H; Omura S;
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正文语种 eng
中图分类药学;
关键词
Amino Acids; L; Following; Beauveria; NOS; 氨基酸类;

机译：Amino Acids;L;Following;Beauveria;NOS;氨基酸类;

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专利

1. New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979. [J] . Matsuda D, Namatame I, Tomoda H, The Journal of Antibiotics: An International Journal . 2004,第1期

机译：氨基酸补充白僵菌发酵产生的新的甜菜碱。 FO-6979。
2. Selective production of fungal beauveriolide I or III by fermentation in amino acid-supplemented media [J] . Hiroshi Tomoda, Yuichi Yamaguchi, Rokuro Masuma, The Journal of Antibiotics: An International Journal . 2002,第12期

机译：通过在氨基酸补充培养基中发酵选择性生成真菌性金紫苏内酯I或III
3. New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties. [J] . Fukuda T, Arai M, Yamaguchi Y, The Journal of Antibiotics: An International Journal . 2004,第2期

机译：新的beauvericins，抗真菌咪康唑活性增强剂，由Beauveria sp。生产。 FKI-1366。 I.分类学，发酵，分离和生物学特性。
4. Sugar-Rich Hydrolyzates from Coffee Pulp Waste which Produced under Solid State Fermentation by Pestalotiosis sp. VM9 and Aspergillus sp. VTM5, and Its Efficiency as Medium for Single Cell Protein Saccharomyces cerevisiae [C] . Syafiq Ubaidillah, Kahar Muzakhar Annual Basic Science International Conference . 2019

机译：来自咖啡纸浆废物的富含糖水解物，该浆料废物通过荚膜病SP通过固态发酵产生。 VM9和Aspergillus sp。 VTM5，其作为单细胞蛋白酿酒酵母酿酒酵母的培养基
5. Extracellular compounds having antibacterial properties produced by the entomopathogenic fungus Beauveria bassiana [D] . Champlin, Franklin Ross 1981

机译：病原真菌球孢白僵菌产生的具有抗菌特性的细胞外化合物
6. Carbohydrate and Amino Acid Fermentation in the Free-Living Primitive Protozoon Hexamita sp. [O] . Giancarlo A. Biagini, Peter S. McIntyre, Bland J. Finlay, 1998

机译：自由原始原生动物Hexamita sp。中的碳水化合物和氨基酸发酵。
7. Bew Beauveriolides Produced by Amino Acid-supplemented Fermentation of Beauveria sp. FO-6979. [O] . DAISUKE MATSUDA, ICHIJI NAMATAME, HIROSHI TOMODA, 2004

机译：Bew Beauveriolides由氨基酸补充发酵的Beauveria sp产生。 FO-6979。

New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.

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