Stemphones,Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus,Produced by Aspergillus sp.FKI-2136

Nobuhiro Koyama; Tomoko Nagahiro; Yuichi Yamaguchi; Rokuro Masuma; Hiroshi Tomoda

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Stemphones,Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus,Produced by Aspergillus sp.FKI-2136

机译：Aspergillus sp.FKI-2136产生的具有抗甲氧西林金黄色葡萄球菌亚胺培南活性的新型增势器

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A fungal strain FKI-2136 identified as genus Aspergillus was found to produce potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus(MRSA).Two new compounds designated stemphones B and C were isolated along with a structurally related known compound cochlioquinone D from the fermentation broth of the producing strain by solvent extraction,silica gel column chromatography and preparative HPLC.These compounds have a common tetracyclic quinone skeleton.Stemphone C potentiated imipenem activity against the MRSA 512 fold by decreasing MIC value of imipenem from 16 mug/ml to 0.03 mug/ml.

机译：发现一种被鉴定为曲霉属的真菌菌株FKI-2136可以产生亚胺培南针对耐甲氧西林金黄色葡萄球菌（MRSA）的增效剂。从发酵过程中分离出两个新化合物，命名为茎杆B和C以及结构上相关的已知化合物耳蜗醌D这些化合物具有共同的四环醌骨架.Stemphone C通过将亚胺培南的MIC值从16杯/毫升降低至0.03杯，增强了对MRSA 512倍的亚胺培南活性。 /毫升。

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来源
《The Journal of Antibiotics: An International Journal》 |2005年第11期|共9页
作者
Nobuhiro Koyama; Tomoko Nagahiro; Yuichi Yamaguchi; Rokuro Masuma; Hiroshi Tomoda;
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正文语种 eng
中图分类药学;
关键词
stemphones; imipenem potentiator; methicillin-resistant Staphylococcus aureus; MRSA; fungal metabolite; tetracyclic quinone;

机译：扩音器;亚胺培南增强剂;耐甲氧西林金黄色葡萄球菌;MRSA;真菌代谢物;四环醌;

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1. Stemphones,Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus,Produced by Aspergillus sp.FKI-2136 [J] . Nobuhiro Koyama, Tomoko Nagahiro, Yuichi Yamaguchi, The Journal of Antibiotics: An International Journal . 2005,第11期

机译：Aspergillus sp.FKI-2136产生的具有抗甲氧西林金黄色葡萄球菌亚胺培南活性的新型增势器
2. New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Streptomyces sp. K04-0144 [J] . Nobuhiro Koyama, Yuriko Tokura, Yoko Takahashi, Acta Pharmaceutica Sinica B . 2011,第4期

机译：新的cyslabdans B和C，亚胺培南针对由链霉菌属产生的耐甲氧西林金黄色葡萄球菌的活性增强剂。 K04-0144
3. Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2 [J] . YamazakiH., ?muraS., TomodaH. The Journal of Antibiotics: An International Journal . 2010,第6期

机译：Xanthoradone C，一种新的亚胺培南活性增强剂，可抵抗耐甲氧西林的金黄色葡萄球菌，由青霉菌FKI-3765-2生产
4. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa. [C] . David Medina, Thomas J. Webster Society for Biomaterials annual meeting and exposition . 2018

机译：金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌（MRSA），大肠杆菌和铜绿假单胞菌制成的具有抗菌特性的生物硒纳米粒子的合成与表征。
5. Isolation of a siderophore produced by methicillin-resistant Staphylococcus aureus strain H372. [D] . Presswood, Rachel Elizabeth. 2010

机译：耐甲氧西林金黄色葡萄球菌菌株H372产生的铁载体的分离。
6. Structure–activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA) [O] . Enrico Speri, Jennifer Fishovitz, Shahriar Mobashery 2018

机译：耐甲氧西林金黄色葡萄球菌（MRSA）抗生素增强剂肉桂酰胺家族的结构-活性关系
7. New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Streptomyces sp. K04-0144 [O] . Nobuhiro Koyama, Yuriko Tokura, Yoko Takahashi, 2011

机译：新的cyslabdans B和C，链霉菌属产生的对耐甲氧西林金黄色葡萄球菌的亚胺培南活性增效剂。 K04-0144

Stemphones,Novel Potentiators of Imipenem Activity against Methicillin-resistant Staphylococcus aureus,Produced by Aspergillus sp.FKI-2136

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