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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Talosins A and B:New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341 I.Taxonomy,Fermentation,Isolation,and Biological Activities
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Talosins A and B:New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341 I.Taxonomy,Fermentation,Isolation,and Biological Activities

机译：Talosins A和B：新奇异黄酮糖苷具有强大的抗真菌活性，来自北风螺菌MJM341 I.分类，发酵，分离和生物学活性

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摘要

In our screening program for new antifungal agents from microbial secondary metabolites,we isolated two new isoflavonol glycosides,genistein 7-alpha-L-6-deoxy-talopyranoside(talosin A)and genistein 4',7-di-alpha-L-6-deoxy-talopyranoside(talosin B),from the culture broth of Kitasatospora kifunensis MJM341.The talosins exhibited strong antifungal activity against Candida albicans,Aspergillus niger and Cryptococcus neoformans with minimal inhibitory concentrations(MIC)in the range of 3 approx 15 mu g/ml while genistein and genistein-7-glucopyranoside did not show antifungal activity at 100 mu g/ml.These talosins are the first isoflavonol glycosides with a 6-deoxy-talose sugar component and they may be useful as antifungal agents with low toxicity because of no visible cytotoxicity against the human hepatic HepG2 cell.
机译：在我们从微生物次生代谢物中筛选新的抗真菌剂的程序中，我们分离了两种新的异黄酮糖苷，染料木素7-α-L-6-脱氧-talopyranoside（talosin A）和染料木素4'，7-di-alpha-L-6 -Kitotospora kifunensis MJM341的培养液中的-deoxy-talopyranoside（talosin B）.talosins对白色念珠菌，黑曲霉和新隐球菌具有较强的抗真菌活性，最小抑菌浓度（MIC）在3约15μg/ g染料木黄酮和染料木黄酮-染料木黄酮苷和染料木黄酮-7-葡萄糖吡喃糖苷在100μg/ ml时未显示出抗真菌活性。对人肝HepG2细胞无可见的细胞毒性。

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