Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

Hideaki Ui; Kazuro Shiomi; Hiroko Hatano; Hiromi Morimoto; Yuichi Yamaguchi; Rokuro Masuma

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Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

机译：Verticipyrone，一种新的NADH富马酸酯还原酶抑制剂，由Verticillium sp。生产。 FKI-1083

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A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC_50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I.

机译：从真菌Verticillium sp。的培养液中分离出一种新的NADH-富马酸酯还原酶抑制剂verticipyrone。 FKI-1083。该结构被确定为（E）-2-甲氧基-3，5-二甲基-6-（3-甲基-2-十一碳烯基）-4H-吡喃-4-酮。 Verticipyrone对A虫的NADH-富马酸酯还原酶的IC_50值为0.88 nM。苯乙酮抑制inhibit虫和牛心复合物I，其合成类似物8,9-二氢-8-羟基维他命酮对A虫复合物I具有良好的选择性。

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来源
《The Journal of Antibiotics: An International Journal》 |2006年第12期|共6页
作者
Hideaki Ui; Kazuro Shiomi; Hiroko Hatano; Hiromi Morimoto; Yuichi Yamaguchi; Rokuro Masuma;
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正文语种 eng
中图分类药学;
关键词
verticipyrone; electron transport enzyme inhibitor; NADH-fumarate reductase;

机译：维替吡酮;电子转运酶抑制剂;富马酸NADH还原酶;

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1. Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083 [J] . Hideaki Ui, Kazuro Shiomi, Hiroko Hatano, The Journal of Antibiotics: An International Journal . 2006,第12期

机译：Verticipyrone，一种新的NADH富马酸酯还原酶抑制剂，由Verticillium sp。生产。 FKI-1083
2. Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389 [J] . Mori M., Morimoto H., Kim Y.-P., Tetrahedron . 2011,第35期

机译：Ukulactones A和B，由青霉属sp。生产的新型NADH-富马酸酯还原酶抑制剂。 FKI-3389
3. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. [J] . Ui H, Shiomi K, Suzuki H, The Journal of Antibiotics: An International Journal . 2006,第9期

机译：Paecilaminoce sp。生产的新型NADH-富马酸酯还原酶抑制剂Paecilaminol。 FKI-0550。
4. ISOLATION OF PHYTOALEXINS FROM INDIGENOUS MALVACEAE SPECIES RESISTANT TO VERTICILLIUM DAHLIAE AND FUSARIUM OXYSPORUM F. SP. VASINFECTUM [C] . Olga Nikolaevna Veshkurova, Zamira Golubenko, Irina Arzanova, Beltwide Cotton Conference . 2006

机译：从土着麦芽糖素物种中植入植物的植物氧脂和镰刀菌镰刀菌的植物脂肪酸素。 vasinfectum.
5. The glucosinolate/myrosinase system: Variation in glucosinolates, hydrolysis products, transcript abundance, and quinone reductase bioactivity in Brassica sp. crops [D] . Becker, Talon M. 2015

机译：芥子油苷/黑芥子酶系统：芸苔属中芥子油苷，水解产物，转录本丰度和醌还原酶生物活性的变化。庄稼
6. Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis [O] . Jun Matsumoto, Kimitoshi Sakamoto, Noriko Shinjyo, 2008

机译：厌氧NADH-富马酸酯还原酶系统是多叶棘球chin的呼吸链中的主导为肺泡棘球osis病的化学治疗提供了一个新的目标。
7. Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083 [O] . Hideaki Ui, Kazuro Shiomi, Hideaki Suzuki, 2006

机译：Verticipyrone是一种新的NADH-富马酸还原酶抑制剂，由Verticillium SP产生。 FKI-1083.

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

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