A Novel,Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation

Makoto Tamaki; Kenta Sawa; Sho Kikuchi

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A Novel,Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation

机译：没有两亲构象的新型的，备有考力霉素S的抗菌活性类似物

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摘要

A novel gramicidin S analog,cyclo(-Val-Leu-Leu-Orn-Leu-D-Phe-Pro-)_2,was synthesized,its antibiotic activity compared with gramicidin S and shown to be as potent as gramicidin S when compared with the susceptibility toward five Gram-positive microorganisms.It exceeded the activity of gramicidin S against Bacillus megaterium ATCC 19213 by a factor of two.Circular dichroism and NMR data suggested this analog to adopt an antiparallel beta-sheet conformation without amphiphilic character.

机译：合成了一种新型的短杆菌肽S类似物，环（-Val-Leu-Leu-Orn-Leu-D-Phe-Pro-）_ 2，与短杆菌肽S相比具有抗菌活性，与短杆菌肽S的杀菌力相同。它对5种革兰氏阳性微生物的敏感性超过了大蒜素S对巨大芽孢杆菌ATCC 19213的活性的两倍。圆形二色性和NMR数据表明，该类似物采用无两亲特性的反平行β-折叠构象。

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《The Journal of Antibiotics: An International Journal》 |2006年第6期|共3页
作者
Makoto Tamaki; Kenta Sawa; Sho Kikuchi;
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正文语种 eng
中图分类药学;
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gramicidin S analog; a potent cyclotetradecapeptide antibiotic; antiparallel beta-sheet conformation; no amphiphilic character; circular dichroism; NMR;

机译：gramicidin S类似物;强效环四肽抗生素;反平行β-折叠构象;无两亲性;圆二色性;NMR;

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1. A Novel,Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation [J] . Makoto Tamaki, Kenta Sawa, Sho Kikuchi The Journal of Antibiotics: An International Journal . 2006,第6期

机译：没有两亲构象的新型的，备有考力霉素S的抗菌活性类似物
2. Environment‐dependent conformation and antimicrobial activity of a gramicidin S analog containing leucine and lysine residues [J] . Aoyagi Haruhiko, Izumiya Nobuo, Kato Tetsuo, FEBS Letters . 1987,第2期

机译：含亮氨酸和赖氨酸残基的大蒜素S类似物的环境依赖性构象和抗菌活性
3. [4,4′‐D‐Diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram‐negative bacteria [J] . Ando Shoji, Aoyagi Haruhiko, Izumiya Nobuo, FEBS Letters . 1983,第1期

机译：[4,4'-D-二氨基丙酸] gramicidin S：具有抗革兰氏阴性菌抗菌活性的合成大蒜素S类似物
4. Antimicrobially Active Analogues of Gramicidin S Having Fatty Acyl Moiety [C] . Yukie Imazeki, Akiko Takashima, Kenta Fujinuma Japanese peptide symposium . 2011

机译：具有脂肪酰基部分的甘霉素S的抗微生物活性类似物
5. Creating Novel Antimicrobial Peptides: From Gramicidin A to Screening a Cyclic Peptide Library [D] . Zerfas, Breanna L. 2017

机译：创建新型抗菌肽：从禾本科A筛选循环肽文库
6. On Resin Amino Acid Side Chain Attachment Strategy for the Head to Tail Synthesis of New Glutamine containing Gramicidin-S Analogs and Their Antimicrobial activity [O] . Safa Derbal, Mary Hensler, Weiqin Fang, -1

机译：在树脂上的氨基酸侧链连接策略的头部包含短杆菌肽-s类似物新谷氨酰胺的尾巴合成及其抗菌活性
7. A Novel, Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation [O] . Makoto Tamaki, Kenta Sawa, Sho Kikuchi, 2006

机译：一种新的，抗微生物活性的葡萄糖蛋白S而不具有两亲构象

A Novel,Antimicrobially Active Analog of Gramicidin S without Amphiphilic Conformation

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