Lepidepyrone,a New gamma-Pyrone Derivative,from Neolentinus lepideus,Inhibits Hyaluronidase

Tomoo Hosoe; Hideo Sakai; Makoto Ichikawa

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Lepidepyrone,a New gamma-Pyrone Derivative,from Neolentinus lepideus,Inhibits Hyaluronidase

机译：Lepidepyrone，一种新型的γ-Pyrone衍生物，来自新轻链霉菌，抑制透明质酸酶

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In the course of screening for hyaluronidase(HAase)inhibitory agents,a new gamma-pyrone derivative,lepidepyrone,C_8H_(10)O_5,was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound(IC_(50)3.3 mM).The structure of lepidepyrone was established on the basis of spectroscopic investigation.

机译：在筛选透明质酸酶（HAase）抑制剂的过程中，从蘑菇新戊香菇TMC-1102的菌丝体中分离出一种新的γ-吡喃酮衍生物，p吡喃酮C_8H_（10）O_5，作为主要的HAase抑制化合物（IC_ （50）3.3 mM）。在光谱学的基础上建立了Lepidepyrone的结构。

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《The Journal of Antibiotics: An International Journal》 |2007年第6期|共3页
作者
Tomoo Hosoe; Hideo Sakai; Makoto Ichikawa;
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正文语种 eng
中图分类药学;
关键词
Neolentinus lepideus; /-pyrone derivative; lepidepyrone; hyaluronidase inhibitor;

机译：轻新镰刀菌;/-吡喃酮衍生物;小肽吡喃酮;透明质酸酶抑制剂;

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1. Lepidepyrone,a New gamma-Pyrone Derivative,from Neolentinus lepideus,Inhibits Hyaluronidase [J] . Tomoo Hosoe, Hideo Sakai, Makoto Ichikawa The Journal of Antibiotics: An International Journal . 2007,第6期

机译：Lepidepyrone，一种新型的γ-Pyrone衍生物，来自新轻链霉菌，抑制透明质酸酶
2. Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors [J] . Kumbar Mahadev N., Kamble Ravindra R., Kamble Atulkumar A., Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2016,第11期

机译：设计，对接研究和分子碘催化合成透明质酸酶抑制剂的苯并[a]黄嘌呤一衍生物
3. Synthesis of sydnone substituted Biginelli derivatives as hyaluronidase inhibitors [J] . GireeshT., KambleR.R., KattimaniP.P., Archiv der Pharmazie . 2013,第9期

机译：sydnone取代的Biginelli衍生物作为透明质酸酶抑制剂的合成
4. New efficient laser dyes for the red region: gamma-pyrone derivatives and phenalemines [C] . I.V. Komlev, Scientific Research Institute of Intermediates, Dy es, International Conference on Atomic and Molecular Pulsed Laser . 1995

机译：用于红色区域的新型高效激光染料：γ-吡喃酮衍生物和非那明胺
5. A Heck-Based Approach to the Synthesis of Anacardic Acids and an Exploration of Its Derivatives as Small-Molecule Inhibitors of the Sumo E1 Enzyme and Aminoalkylation of Adamantanes Using Dual Photoredox-Hat Catalysis [D] . Weigel, William Kenneth, III. 2020

机译：一种基于Heck的嗜酸性酸合成的方法和衍生物作为Sumo E1酶的小分子抑制剂的探索，使用双光毒毒帽催化与氨烷烷的氨基烷基化物
6. Synthesis and biological evaluations of oleanolic acid indole derivatives as hyaluronidase inhibitors with enhanced skin permeability [O] . Hao He, Huifang Li, Toyosi Akanji, 2021

机译：单溶胶吲哚衍生物作为透明质酸酶抑制剂的合成与生物学评价具有增强的皮肤渗透性
7. Novel tyrosinase inhibitors from liquid culture of Neolentinus lepideus [O] . Atsushi Ishihara, Yuri Ide, Tomohiro Bito, 2018

机译：新芽素叶片液体培养的新型酪氨酸酶抑制剂
8. Fluorometric Determination of Hyaluronidase and Cu(11), Fe(11), and Cyanide Ion Inhibitors [R] . Guilbault, G. G., Kramer, D. N., Hackley, E. 1967

机译：荧光法测定透明质酸酶和Cu（11），Fe（11）和氰化物离子抑制剂

Lepidepyrone,a New gamma-Pyrone Derivative,from Neolentinus lepideus,Inhibits Hyaluronidase

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