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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Nigerasperones A approximately C, new monomeric and dimeric naphtho-gamma-pyrones from a marine alga-derived endophytic fungus Aspergillus niger EN-13.
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Nigerasperones A approximately C, new monomeric and dimeric naphtho-gamma-pyrones from a marine alga-derived endophytic fungus Aspergillus niger EN-13.

机译：Nigerasperones一种来自海藻来源的内生真菌黑曲霉EN-13的大约C，新的单体和二聚萘-γ-吡喃酮。

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摘要

Three new naphtho-gamma-pyrones, 5-hydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-naphtho[2,3-b]pyran-4-one (1, nigerasperone A), 3,3'-dihydro-2,2',5,5'-tetrahy-droxy-8,8',10,10'- tetramethoxy-2,2'-dimethyl-(6',9-bi-4H-naphtho[1,2-b]pyran)-4,4'-dione (2, nigerasperone B), and 3'-hydro-2',5,5',8-tetrahydroxy-6,6',8'-trimethoxy-2,2'-dimethyl-(7,10'-bi-4H-nap htho[2,3-b]pyran)-4,4'-dione (3, nigerasperone C), together with nine related known compounds were characterized from Aspergillus niger EN-13, an endophytic fungus isolated from the marine brown alga Colpomenia sinuosa. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with literature reports. In the cytotoxic assay, these compounds did not show remarkable inhibitory effects against A549 and SMMC-7721 tumor cell lines. However, 3 and several known compounds showed weak antifungal activity against Candida albicans and moderate activity on DPPH scavenging.
机译：三个新的萘-γ-吡喃酮，5-羟基-6,8-二甲氧基-2-羟基甲基-4H-萘并[2,3-b]吡喃-4-酮（1，尼培拉酮A），3,3'-二氢-2,2'，5,5'-四羟基-8,8'，10,10'-四甲氧基-2,2'-二甲基-（6'，9-bi-4H-萘[1,2- b] pyran）-4,4'-dione（2，nigerasperone B）和3'-hydro-2'，5,5'，8-tetrahydroxy-6,6'，8'-trimethoxy-2,2'从黑曲霉EN中鉴定了-二甲基-（7,10'-bi-4H-nap [2,3-b]吡喃）-4,4'-二酮（3，nigerasperone C）以及九种相关已知化合物-13是从海洋褐藻中华大螯虾中分离出的一种内生真菌。通过详细分析光谱数据并与文献报告进行比较，阐明了它们的结构。在细胞毒性测定中，这些化合物对A549和SMMC-7721肿瘤细胞系没有明显的抑制作用。但是，3种和几种已知化合物对白色念珠菌的抗真菌活性较弱，对DPPH清除的活性中等。

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