Trierixin,a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.I.Taxonomy,Fermentation,Isolation,and Biological Activities

Etsu Tashiro; Naoka Hironiwa; Mitsuhiro Kitagawa

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Trierixin,a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.I.Taxonomy,Fermentation,Isolation,and Biological Activities

机译：Trierixin，一种新的内质网链霉菌ER应力诱导的XBP1活化的抑制剂I.分类，发酵，分离和生物活性

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In the course of screening for an inhibitor of ER stress-induced XBP1 activation,we isolated a new member of the triene-ansamycin group compound,trierixin,from a culture broth of Streptomyces sp.AC 654.Trierixin was purified by column chromatography on silica gel and by HPLC.The molecular formula of trierixin is C_(37)H_(52)N2O8S.Trierixin inhibited thapsigargin-induced XBP1-luciferase activation in HeLa/XBP1-luc cells and endogenous XBP1 splicing in HeLa cells with an IC_(50)of 14ng/ml and 19ng/ml,respectively.Moreover,in the process of isolating trierixin,we isolated structurally related mycotrienin II and trienomycin A as inhibitors of ER stress-induced XBP1 activation from a culture broth of a trierixin-producing strain.This study provides the first observation that triene-ansamycins have a novel inhibitory effect against XBP1 activation.

机译：在筛选内质网应激诱导的XBP1活化的抑制剂的过程中，我们从链霉菌AC 654的培养液中分离出了三烯-红霉素类化合物的新成员trierixin。 Trierixin的分子式为C_（37）H_（52）N2O8S.Trierixin抑制thapsigargin诱导的HeLa / XBP1-luc细胞中XBP1-荧光素酶的活化，并通过IC_（50）抑制HeLa细胞内源性XBP1剪接。此外，在分离trierixin的过程中，我们从产生trierixin的菌株的培养液中分离了结构相关的霉菌毒素II和曲霉霉素A作为ER应激诱导的XBP1活化的抑制剂。这项研究首次发现三烯-红霉素对XBP1活化具有新的抑制作用。

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《The Journal of Antibiotics: An International Journal》 |2007年第9期|共7页
作者
Etsu Tashiro; Naoka Hironiwa; Mitsuhiro Kitagawa;
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正文语种 eng
中图分类药学;
关键词
trierixin; triene-ansamycin; ER stress; XBP1;

机译：Trierixin;三烯-红霉素;内质网应激;XBP1;

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1. Trierixin,a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.I.Taxonomy,Fermentation,Isolation,and Biological Activities [J] . Etsu Tashiro, Naoka Hironiwa, Mitsuhiro Kitagawa The Journal of Antibiotics: An International Journal . 2007,第9期

机译：Trierixin，一种新的内质网链霉菌ER应力诱导的XBP1活化的抑制剂I.分类，发酵，分离和生物活性
2. A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities. [J] . Solecka J, Rajnisz A, Laudy AE The Journal of Antibiotics: An International Journal . 2009,第10期

机译：一种新型的异喹啉生物碱，DD-羧肽酶抑制剂，具有抗菌活性，可从链霉菌中分离得到。 8812.第一部分：分类学，发酵，分离和生物活动。
3. Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. I. Screening, taxonomy, fermentation, isolation and biological properties. [J] . Furumai T, Yamakawa T, Yoshida R, The Journal of Antibiotics: An International Journal . 2003,第8期

机译：克雷霉素，一种新的花粉管生长抑制剂，具有吸湿链霉菌TP-A0623的抗真菌活性。 I.筛选，分类，发酵，分离和生物学特性。
4. PACAP Inhibits Oxidative Stress-Induced Activation of MAP Kinase-Dependent Apoptotic Pathway in Cultured Cardiomyocytes [C] . BALAZS GASZ, BOGLARKA RACZ, ERZSEBET ROTH, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：PACAP抑制氧化应激诱导的MAP激酶依赖性凋亡途径在培养的心肌细胞中的激活
5. Chemical and cell biological approaches to study ER stress-induced apoptosis. [D] . Boyce, Michael. 2005

机译：化学和细胞生物学方法来研究内质网应激诱导的细胞凋亡。
6. Identification of Toyocamycin an agent cytotoxic for multiple myeloma cells as a potent inhibitor of ER stress-induced XBP1 mRNA splicing [O] . M Ri, E Tashiro, D Oikawa, 2012

机译：鉴定Toyocamycin一种对多发性骨髓瘤细胞具有细胞毒性的药物作为ER应激诱导的XBP1 mRNA剪接的有效抑制剂
7. Trierixin, a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp. [O] . Yushi Futamura, Etsu Tashiro, Naoka Hironiwa, 2007

机译：Trierixin，一种新的ER应激诱导的XBP1激活来自链霉菌SP的新型抑制剂。

Trierixin,a Novel Inhibitor of ER Stress-induced XBP1 Activation from Streptomyces sp.I.Taxonomy,Fermentation,Isolation,and Biological Activities

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