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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Novel GRP78 Molecular Chaperone Expression Down-regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger
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Novel GRP78 Molecular Chaperone Expression Down-regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger

机译：分离自链霉菌的新型GRP78分子伴侣表达下调剂JBIR-04和-05

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摘要

In the course of our screening program for regulators of the expression of GRP78 molecular chaperone,JBIR-04 (1) and -05 (2) were isolated from Streptomyces violaceoniger 4541-SVS3 as congeners of prunustatin A (3).The structures of 1 and 2 were determined by the analyses of the spectroscopic data.These compounds mainly consist of an amino acid and amino acid derived alpha-hydroxy acid residues.1 and 2 inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells,but their activities were highly reduced compared with those of 3 and SW-163A.
机译：在我们筛选GRP78分子伴侣表达调控剂的程序中，从紫链霉菌4541-SVS3中分离出JBIR-04（1）和-05（2）作为苦杏仁苷A的同源物（3）。结构1通过光谱数据分析确定了其中的2和2。这些化合物主要由氨基酸和氨基酸衍生的α-羟基残基组成。1、2抑制2-脱氧葡萄糖诱导的人纤维肉瘤HT1080细胞中GRP78的表达，与3和SW-163A相比，它们的活性大大降低。

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