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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Nigerasperones A~C,New Monomeric and Dimeric Naphtho-gamma-pyrones from a Marine Alga-derived Endophytic Fungus Aspergillus niger EN-13
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Nigerasperones A~C,New Monomeric and Dimeric Naphtho-gamma-pyrones from a Marine Alga-derived Endophytic Fungus Aspergillus niger EN-13

机译：Nigerasperones A〜C，来自海洋藻类内生真菌黑曲霉EN-13的新的单体和二聚萘-γ-吡喃酮

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摘要

Three new naphtho-gamma-pyrones,5-hydroxy-6,8-dimethoxy-2-hydroxymethyl-4H-naphtho[2,3-b]pyran-4-one(1,nigerasperone A),3,3'-dihydro-2,2',5,5'-tetrahy-droxy-8,8',10,10'-tetramethoxy-2,2'-dimethyl-(6',9-bi-4H-naphtho[l,2-b]pyran)-4,4'-dione(2,nigerasperone B),and 3'-hydro-2',5,5',8-tetrahydroxy-6,6',8'-trimethoxy-2,2'-dimethyl-(7,10'-bi-4H-naphtho[2,3-b]pyran)-4,4'-dione(3,nigerasperone C),together with nine related known compounds were characterized from Aspergillus niger EN-13,an endophytic fungus isolated from the marine brown alga Colpomenia sinuosa.Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with literature reports.In the cytotoxic assay,these compounds did not show remarkable inhibitory effects against A549 and SMMC-7721 tumor cell lines.However,3 and several known compounds showed weak antifungal activity against Candida albicans and moderate activity on DPPH scavenging.
机译：三个新的萘-γ-吡喃酮，5-羟基-6,8-二甲氧基-2-羟基甲基-4H-萘并[2,3-b]吡喃-4-酮（1，尼加倍酮A），3,3'-二氢-2,2'，5,5'-四羟基-8,8'，10,10'-四甲氧基-2,2'-二甲基-（6'，9-bi-4H-萘[1,2- b] pyran）-4,4'-dione（2，nigerasperone B）和3'-hydro-2'，5,5'，8-tetrahydroxy-6,6'，8'-trimethoxy-2,2'从黑曲霉EN-中鉴定了-二甲基-（7,10'-bi-4H-萘并[2,3-b]吡喃）-4,4'-二酮（3，nigerasperone C）以及九种相关的已知化合物13，从海藻褐藻中分离出的一种内生真菌。通过光谱数据的详细分析和与文献报道的比较，阐明了它们的结构。在细胞毒性试验中，这些化合物对A549和SMMC-7721没有明显的抑制作用。然而，3和几种已知化合物对白色念珠菌的抗真菌活性较弱，对DPPH的清除具有中等活性。

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