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首页> 外文期刊>The Journal of Antibiotics: An International Journal >A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus
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A New Cadinane Sesquiterpene with Significant Anti-HIV-1 Activity from the Cultures of the Basidiomycete Tyromyces chioneus

机译:一种新的具有显着抗HIV-1活性的卡丁烷倍半萜烯,来自拟南芥(Basidiomycete Tyromyces chioneus)培养

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摘要

A new cadinane sesquiterpene (4/3,14-dihydroxy-6alpha,7beta H-l(10)-cadinene,1) was isolated from the cultures of the basidiomycete,Tyromyces chioneus.Its structure was established on the basis of spectral measurements (MS,IR,ID and 2D NMR experiments).1 showed significant anti-HIV-1 activity with EC50=3.0 mu g/ml (SI=25.4).
机译:从basidiomycete,Tyromyces chioneus的培养物中分离出一种新的卡丹烷倍半萜烯(4 / 3,14-dihydroxy-6alpha,7beta Hl(10)-cadinene,1),并根据光谱测量(MS, IR,1D和2D NMR实验).1显示了显着的抗HIV-1活性,EC50 = 3.0μg / ml(SI = 25.4)。

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