Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

Fiedler HP; Dieter A; Gulder TA; Kajahn I; Hamm A; Brown R; Jones AL; Goodfellow M; Muller WE; Bringmann G

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Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

机译：链霉菌属菌种产生的Genoketides A1和A2，新的octaketides和菜豆酚的生物合成中间体。 AK 671。

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The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

机译：新的芳族聚酮化合物基因okeA1，基因okeA2和前胡酚醇葡糖醛酸苷是八肽胡酚醇的生物合成中间体。它们从嗜碱菌株链霉菌（Streptomyces sp。）分离。 AK 671与新的代谢物香豆酚葡糖醛酸。通过质谱和NMR方法阐明了化合物的结构。 Genoketide A2表现出轻微的和前ch酚葡萄糖醛糖苷酸对L5178y淋巴瘤细胞增殖的抑制作用更为明显。

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《The Journal of Antibiotics: An International Journal》 |2008年第7期|共10页
作者
Fiedler HP; Dieter A; Gulder TA; Kajahn I; Hamm A; Brown R; Jones AL; Goodfellow M; Muller WE; Bringmann G;
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1. Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671. [J] . Fiedler HP, Dieter A, Gulder TA, The Journal of Antibiotics: An International Journal . 2008,第7期

机译：链霉菌属菌种产生的Genoketides A1和A2，新的octaketides和菜豆酚的生物合成中间体。 AK 671。
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7. Biosynthetic capacities of actinomycetes. 46. Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671 [O] . Fiedler, H.-P., Dieter, A., Gulder, T.A.M., 2008

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8. Physiological Evaluation of A1 (Extreme-Cold-Weather) and A2 (Buoyant, Intermediate-Cold-Weather) Jackets [R] . Avellini, B. A. 1983

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Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671.

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