Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.

Sohn MJ; Zheng CJ; Kim WG

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Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.

机译：Macrolactin S，一种新型细菌，具有芽孢杆菌属的FabG抑制活性。 AT28。

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In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound macrolactin B, has been isolated from the mycelium of liquid fermentation cultures of Bacillus sp. AT28. The structure of macrolactin S was determined on the basis of MS and NMR data. Macrolactin S showed a dose-dependent inhibition of Staphylococcus aureus FabG, not inhibiting S. aureus FabI. Also macrolactin S inhibited the growth of S. aureus, Bacillus subtilis, and Escherichia coli.

机译：在从微生物来源筛选FabG抑制剂的过程中，从芽孢杆菌属的液体发酵培养菌丝体中分离了一种新的24元环内酯，称为大内泌素S，以及已知的化合物大内泌素B。 AT28。根据MS和NMR数据确定大内酰胺S的结构。 Macrolactin S显示出金黄色葡萄球菌FabG的剂量依赖性抑制，而不抑制金黄色葡萄球菌FabI。另外，大乳素S也抑制金黄色葡萄球菌，枯草芽孢杆菌和大肠杆菌的生长。

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《The Journal of Antibiotics: An International Journal》 |2008年第11期|共5页
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Sohn MJ; Zheng CJ; Kim WG;
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正文语种 eng
中图分类药学;
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1. Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28. [J] . Sohn MJ, Zheng CJ, Kim WG The Journal of Antibiotics: An International Journal . 2008,第11期

机译：Macrolactin S，一种新型细菌，具有芽孢杆菌属的FabG抑制活性。 AT28。
2. Macrolactin W, a new antibacterial macrolide from a marine Bacillus sp. [J] . Mondol MA, Kim JH, Lee HS, Bioorganic and Medicinal Chemistry Letters . 2011,第12期

机译：Macrolactin W，一种来自海洋芽孢杆菌属的新型抗菌大环内酯。
3. THE EFFECT OF MEDIA AND FERMENTATION CONDITION TOWARD ANTIBACTERIAL ACTIVITIES OF BACILLUS SP. DA11 ASSOCIATED WITH SARCOPHYTON SP. [J] . R. Nofiani, R. D. Arisandi, P. Ardiningsih International Journal of Pharmaceutical Sciences and Research . 2019,第7期

机译：培养基和发酵条件对芽孢杆菌抗菌活性的影响。与SARCOPHYTON SP相关的DA11。
4. Ecology and activity of two endophytic isolates of Bacillus sp. effective as biocontrol agents against Verticillium dahliae of solanaceous hosts [C] . S. E. Tjamos, A. Venieraki, D. I. Tsisiyiannis, International Verticillium Symposium . 2000

机译：芽孢杆菌两种内心分离株的生态学和活性。作为针对溶律宿主的患者的生物控制剂有效
5. Bacillus sp. su?lar?ndan Lipaz taranmas?, Lipaz üretim ko?ullar?n?n Optimizasyonu, k?smi safla?t?r?lmas?, Karakterizasyonu Ve Deterjan endüstrisindeki Potansiyel uygulamalar? =Screening of lipase from Bacillus sp. strains, optimization of lipase productio [D] . Abdou, Maoulida. 2019

机译：Bacillus sp。脂肪酶生产的优化KO？ULLAR？ =来自芽孢杆菌SP的脂肪酶的筛选。脂肪酶产品的菌株，优化
6. 7-O-Malonyl Macrolactin A a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus Vancomycin-Resistant Enterococci and a Small-Colony Variant of Burkholderia cepacia [O] . Magally Romero-Tabarez, Rolf Jansen, Marita Sylla, 2006

机译：7-O-丙二酸Macrolactin A一种来自枯草芽孢杆菌的新型Macrolactin抗生素具有抗耐甲氧西林的金黄色葡萄球菌耐万古霉素的肠球菌和洋葱伯克霍尔德菌的小菌落变体
7. Structure Determination of Macrolactin Compounds with Antibacterial Activities Isolated from Bacillus polyfermenticus KJS-2 [O] . Dong-Hee Kim, Kyung-Ran Kang, Hyun-Woo Kim, 2010

机译：从芽孢杆菌聚糖中分离的抗菌活性的致癌活性的结构测定kjs-2

Macrolactin S, a new antibacterial agent with FabG-inhibitory activity from Bacillus sp. AT28.

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