Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520 - I. Taxonomy, fermentation, isolation and biological activities

Suzuki K.; Monnai Y.; Yagi A.; Uyeda M.; Nagao K.

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Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520 - I. Taxonomy, fermentation, isolation and biological activities

机译：Topostatin，一种新的拓扑异构酶I和II抑制剂，由白热单孢菌1520-I产生。分类学，发酵，分离和生物学活性

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A novel inhibitor of topoisomerases designated as topostatin was isolated from the culture filtrate of Thermomonospora alba strain No. 1520. Topostatin inhibited the relaxation of supercoiled pBR322 DNA by calf thymus topoisomerase I, and also inhibited the relaxation of supercoiled pBR322 DNA and decatenation of kinetoplast DNA by human placenta topoisomerase II. Topostatin had neither ability to stabilize the cleavable complex nor ability to intercalate into DNA strands. The inhibitor exhibited growth inhibitory activity against the tumor cells (SNB-75 and SNB-78) of central nervous system, but did not exhibit any antimicrobial activity against Gram-positive and Gram-negative bacteria, yeasts and fungi. [References: 32]

机译：从白热单孢菌菌株No.1520的培养滤液中分离出一种新的拓扑异构酶抑制剂，称为topostatin。Topostatin抑制小胸腺拓扑异构酶I抑制超螺旋pBR322 DNA的松弛，也抑制超螺旋pBR322 DNA的松弛和运动塑料DNA的解构。通过人类胎盘拓扑异构酶II。 Topostatin既没有稳定可裂解复合物的能力，也没有插入DNA链的能力。该抑制剂对中枢神经系统的肿瘤细胞（SNB-75和SNB-78）具有生长抑制活性，但对革兰氏阳性和革兰氏阴性细菌，酵母菌和真菌没有任何抗菌活性。 [参考：32]

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《The Journal of Antibiotics: An International Journal》 |1998年第11期|共8页
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Suzuki K.; Monnai Y.; Yagi A.; Uyeda M.; Nagao K.;
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1. Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520 - I. Taxonomy, fermentation, isolation and biological activities [J] . Suzuki K., Monnai Y., Yagi A., The Journal of Antibiotics: An International Journal . 1998,第11期

机译：Topostatin，一种新的拓扑异构酶I和II抑制剂，由白热单孢菌1520-I产生。分类学，发酵，分离和生物学活性
2. Epostatin, new inhibitor of dipeptidyl peptidase II, produced by Streptomyces sp. MJ995-OF5 - I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties and biological properties [J] . Akiyama T., Kojima F., Kinoshita N., The Journal of Antibiotics: An International Journal . 1998,第3期

机译：Epostatin，链霉菌属sp。生产的二肽基肽酶II的新抑制剂。 MJ995-OF5-I.生产菌株的分类，发酵，分离，理化特性和生物学特性
3. PF1163A and B, new antifungal antibiotics produced by Penicillium sp I. Taxonomy of producing strain, fermentation, isolation and biological activities [J] . Nose H., Yaguchi T., Hosoya A., The Journal of Antibiotics: An International Journal . 2000,第1期

机译：PF1163A和B，由青霉属I生产的新型抗真菌抗生素。产生菌株，发酵，分离和生物学活性的分类
4. Isolation and Identification of an Inulinase-Producing Strain and the Optimization of Its Fermentation Condition [C] . Yang Zhang, Hongyang Zhu, Jinhai Wang, International conference on applied biotechnology . 2015

机译：菊粉酶生产菌的分离鉴定及其发酵条件的优化
5. Part I. Isolation of natural product inhibitors and synthesis of inhibitors of signal transduction. Part II. Structure-activity relationship for a series of glycosidase inhibitors. [D] . Fraser, Rebecca Dawn. 1993

机译：第一部分：天然产物抑制剂的分离和信号转导抑制剂的合成。第二部分一系列糖苷酶抑制剂的构效关系。
6. Correction: Singh, M.P., et al. Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities [O] . Maya P. Singh, Jeffrey E. Janso, Sean F. Brady 2018

机译：校正：Singh，M.P.等。 Cytospora sp。生产的Cytoskyrins和Cytosporones。 CR200：分类学，发酵和生物活动
7. Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520. I. Taxonomy, Fermentation, Isolation and Biological Activities. [O] . KEITAROU SUZUKI, KAZUHIKO NAGAO, YUTAKA MONNAI, 1998

机译：Topostatin，由Thermomonospora Alba菌株No.1520产生的拓扑异构酶I和II的新型抑制剂。I.分类，发酵，分离和生物活性。

Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520 - I. Taxonomy, fermentation, isolation and biological activities

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