Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin.

Hirose T; Sunazuka T; Sugawara A; Noguchi Y; Tanaka T; Iguchi K; Yamamoto T; Gouda H; Shiomi K; Omura S

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin.

【24h】

Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin.

机译：使用负载的缩醛树脂进行几丁质酶抑制剂Argadin的固相全合成。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A versatile solid-phase total synthesis was applied to the rapid preparation of Argadin, a natural product isolated and characterized as a cyclopentapeptide by our group, which possesses superior inhibitory activity against family-18 chitinases. The synthetic strategy includes peptide synthesis by using an Fmoc (9-fluorenylmethoxycarbonyl) protective group, macrolactamization, acetylguanylation and formation of hemiaminal accompanied by total deprotection, including cleavage from resin.

机译：一种通用的固相全合成技术被用于Argadin的快速制备，Argadin是我们小组分离并表征为环五肽的天然产物，对18号家庭几丁质酶具有出色的抑制活性。合成策略包括通过使用Fmoc（9-芴基甲氧基羰基）保护基进行肽合成，大内酰胺化，乙酰胍基化和半胱氨酸的形成，同时进行完全脱保护，包括从树脂上裂解。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2009年第9期|共6页
作者
Hirose T; Sunazuka T; Sugawara A; Noguchi Y; Tanaka T; Iguchi K; Yamamoto T; Gouda H; Shiomi K; Omura S;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin. [J] . Hirose T, Sunazuka T, Sugawara A, The Journal of Antibiotics: An International Journal . 2009,第9期

机译：使用负载的缩醛树脂进行几丁质酶抑制剂Argadin的固相全合成。
2. Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold [J] . Mark J. Dixon, Amit Nathubhai, Ole A. Andersen, Organic & biomolecular chemistry . 2009,第1期

机译：环肽几丁质酶抑制剂的固相合成：argifin支架的SAR
3. A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A [J] . Yusuke Iijima, Asami Munakata, Kazuo Shin-ya Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2009,第24期

机译：环状二肽HDAC抑制剂spiruchostatin A的固相全合成
4. Synthesis and Structure-based Dissection of Cyclic Peptide Chitinase Inhibitors: New Leads for Antifungal and Anti-Inflammatory Drugs [C] . Mark J. Dixon, Amit Nathubhai, Ole A. Andersen American Peptide Symposium . 2009

机译：环肽丁醇蛋白酶抑制剂的合成和结构析出：抗真菌和抗炎药的新铅
5. Synthesis of side chain-modified iodothyronines. Synthesis and structure-activity relationships (SARS) of galanthamine derivatives. Total synthesis of (+)-valyldetoxinine. Synthesis and mechanism of cyclic acetal and ketal formation in pentono-1,4-lactones. [D] . Han, So-Yeop. 1992

机译：侧链修饰的碘甲状腺素的合成。加兰他敏衍生物的合成及其构效关系（SARS）。（+）-Valyldetoxinine的全合成。戊通-1,4-内酯中环状缩醛和缩酮的合成及其机理。
6. Recent development of two chitinase inhibitors Argifin and Argadin produced by soil microorganisms [O] . Tomoyasu Hirose, Toshiaki Sunazuka, Satoshi Ōmura 2010

机译：土壤微生物产生的两种几丁质酶抑制剂Argifin和Argadin的最新进展
7. Correction:First synthesis of argadin: a nanomolar inhibitor of family-18 chitinases [O] . Dixon, Mark J., Andersen, Ole A., van Aalten, Daan M. F., 2006

机译：更正：首次合成精氨酸：18家族几丁质酶的纳摩尔抑制剂

Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin.

摘要

著录项

相似文献

相关主题

期刊订阅