Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.

Xiang WS; Wang JD; Wang XJ; Zhang J

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Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.

机译：Bingchamides A和B，两个来自炳城链霉菌的新型环状五肽：发酵，分离，结构解析和生物学特性。

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Two novel cyclic pentapeptides, bingchamides A (1) and B (2), have been isolated from the organic extracts of the mycelium of Streptomyces bingchenggensis. The structures of 1 and 2 were elucidated on the basis of extensive 1D and 2D NMR, as well as HRESI-MS, electrospray ionization-MS, UV and IR spectroscopic data analysis. Bingchamides A (1) and B (2) exhibited in vitro cytotoxicity toward human colon carcinoma cell line HCT-116 with the IC(50) values of 14.1 and 18.0 microg ml(-1), respectively. The bingchamides A (1) and B (2) scaffolds are probably promising structures for the development of new antitumor agents.

机译：两种新的五环肽，bingchamides A（1）和B（2），已从bingchenggensis链霉菌菌丝体的有机提取物中分离出来。在广泛的1D和2D NMR以及HRESI-MS，电喷雾电离MS，UV和IR光谱数据分析的基础上阐明了1和2的结构。 Bingchamides A（1）和B（2）对人结肠癌细胞系HCT-116表现出体外细胞毒性，IC（50）值分别为14.1和18.0 microg ml（-1）。 bingchamides A（1）和B（2）支架可能是开发新抗肿瘤药物的有前途的结构。

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《The Journal of Antibiotics: An International Journal》 |2009年第9期|共5页
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Xiang WS; Wang JD; Wang XJ; Zhang J;
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正文语种 eng
中图分类药学;
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1. Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties. [J] . Xiang WS, Wang JD, Wang XJ, The Journal of Antibiotics: An International Journal . 2009,第9期

机译：Bingchamides A和B，两个来自炳城链霉菌的新型环状五肽：发酵，分离，结构解析和生物学特性。
2. Two New beta-Class Milbemycins from Streptomyces bingchenggensis:Fermentation,Isolation,Structure Elucidation and Biological Properties [J] . Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang The Journal of Antibiotics: An International Journal . 2007,第6期

机译：炳城链霉菌的两种新的β-类米尔倍霉素的发酵，分离，结构解析及生物学特性
3. New Seco-milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation and Structure Elucidation. [J] . Xiang WS, Wang JD, Fan HM, The Journal of Antibiotics: An International Journal . 2008,第1期

机译：bingchenggensis链霉菌的新型Seco-milbemycins：发酵，分离和结构解析。
4. N-Methylated Cyclic Pentapeptides as Template Structures [C] . Jayanta Chatterjee, Oded Ovadia, Chaim Gilon American Peptide Symposium . 2009

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5. Use of adsorbent resins in fermentations of bacteria obtained from the red soils of the kingdom of Jordan and the isolation and structure elucidation of cytotoxic xanthones from an unidentified fungus. [D] . Johnston, Thomas A. 2011

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7. Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties [O] . Wen-Sheng Xiang, Ji-Dong Wang, Xiang-Jing Wang, 2009

机译：BingChamides A和B，来自链霉菌的两种新的环状五肽：发酵，分离，结构阐明和生物学性质

Bingchamides A and B, two novel cyclic pentapeptides from the Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.

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