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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Hatomarubigin E, a biosynthetic intermediate of hatomarubigins C and a substrate of HrbU O-methyltransferase.
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Hatomarubigin E, a biosynthetic intermediate of hatomarubigins C and a substrate of HrbU O-methyltransferase.

机译：Hatomarubigin E是Hatomarubigins C的生物合成中间体，是HrbU O-甲基转移酶的底物。

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摘要

The angucycline antibiotics1,2 are characterized by containing the modified benz[a]anthraquinone chromophore and show antimicrobial, antitumor and/or enzyme-inhibitory activities. Streptomyces sp. 2238-SVT4 produced four angucyclines, hatomarubigins A, B, C and D (Figure 1a), which enhanced the cytotoxicity of colchicine in multidrug-resistant tumor cells.3 Recently, we identified the hrb gene cluster as consisting of hatomarubigin biosynthesis genes belonging to Streptomyces sp. 2238-SVT4.4 Several genes in the hrb cluster showed no homology to angucycline biosynthesis genes as previously reported. To clarify the function of hrb genes, biosynthetic intermediates of hatomarubigins were searched for in the culture extract. Color-guided fractionation resulted in the isolation of a new metabolite, hatomarubigin E (1). Herein, we report the isolation, structure elucidation and enzymatic conversion of 1.
机译：安古环素抗生素1,2的特征是含有修饰的苯并[a]蒽醌发色团，并显示出抗菌，抗肿瘤和/或酶抑制活性。链霉菌2238-SVT4产生了四种金环素，即金红霉素A，B，C和D（图1a），从而增强了秋水仙碱在多药耐药肿瘤细胞中的细胞毒性。3最近，我们鉴定了hrb基因簇，该基因簇由金红霉素生物合成基因组成链霉菌2238-SVT4.4 hrb簇中的几个基因没有显示出与先前所报道的古环素生物合成基因同源。为了阐明hrb基因的功能，在培养物中提取了Hatomarubigins的生物合成中间体。颜色引导分馏导致分离出新的代谢产物Hatomarubigin E（1）。在此，我们报告1.的分离，结构阐明和酶促转化。

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