Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin

Yoshitaka Matsushima; Takuya Nakayama; Masaki Fujita; Renuka Bhanari; Tadashi Eguchi; Kazutoshi Shindo; Katsumi Kakinuma

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Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin

机译：Vicenistatin M的分离和结构鉴定，以及Visnisamine氨基糖对Visistatin的细胞毒性的重要性

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A new analogue of vicenistatin was isolated from the producing strain Streptomyces sp.HC-34. Acharacteristic of hte elucideated structure involved the existence of a neutral sugar mycarose instead of an aminosugar vicenisamine of vicenistatin. The absolute stereochemistry of the new analogue (named as vicenistatin M) was determined by the synthesis of D-mycarose and of vicenistatin M itself. Biological testing of vicenistatin M suggested the importance of vicenisamine for exerting the cytotoxicity of vicenistatin.

机译：从生产菌株Streptomyces sp.HC-34中分离出了维斯他汀的新类似物。阐明的结构的特征包括存在中性糖Mycarose而不是Vicenistatin的氨基糖Vicenisamine。新类似物（称为维斯他汀M）的绝对立体化学是由D-支链淀粉和维斯他汀M本身的合成决定的。 Vicenistatin M的生物学测试表明，Visnisatin对发挥Visnistatin的细胞毒性作用非常重要。

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《The Journal of Antibiotics: An International Journal》 |2001年第3期|共9页
作者
Yoshitaka Matsushima; Takuya Nakayama; Masaki Fujita; Renuka Bhanari; Tadashi Eguchi; Kazutoshi Shindo; Katsumi Kakinuma;
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正文语种 eng
中图分类药学;药品;
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Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin

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