RP-1776,a Novel Cyclic Peptide Produced by Streptomyces sp.,Inhibits the binding of PDGF to the Extracellular Domain of Its Receptor

Shinichiro Toki; Tsutomu Agatsuma; Keiko Ochiai; Yutaka Saitoh; Katsuhiko Ando; Satoshi Nakanishi; Natalie A.Lokker; Neill A.Giese; Yuzuru Matsuda

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RP-1776,a Novel Cyclic Peptide Produced by Streptomyces sp.,Inhibits the binding of PDGF to the Extracellular Domain of Its Receptor

机译：RP-1776，由链霉菌属产生的一种新型环肽，抑制PDGF与其受体的胞外域结合

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RP-1776,a novel cyclic peptide,was isolated from the culture broth of Streptomyces sp.KY11784.RP-1776 selectively inhibited the binding of PDGF BB to the extracellular domain ofthe PDGF #beta#-receptor with an IC_(50) value of 11(+-)6#mu#M.Detailed bindign experiments suggested that RP-1776 directly interacts with PDGF BB.RP-1776 inhibited the phosphorylation of the DPGF #beta#-receptor induced by PDGF BB.These results suggested that RP-176 antagonizes the signaling of PDGF BB probably through the inhibition of PDGF BB binding to the PDGF #beta#-receptor.

机译：从链霉菌KY11784的培养液中分离出一种新型环肽RP-1776.RP-1776选择性抑制PDGF BB与PDGF＃beta＃受体胞外域的结合，IC_（50）值为11（+-）6＃mu＃M。详细的结合实验表明RP-1776直接与PDGF BB相互作用.RP-1776抑制了PDGF BB诱导的DPGF＃β＃受体的磷酸化，这些结果表明RP- 176可能通过抑制PDGF BB与PDGF＃beta＃受体的结合来拮抗PDGF BB的信号。

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《The Journal of Antibiotics: An International Journal》 |2001年第5期|共10页
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Shinichiro Toki; Tsutomu Agatsuma; Keiko Ochiai; Yutaka Saitoh; Katsuhiko Ando; Satoshi Nakanishi; Natalie A.Lokker; Neill A.Giese; Yuzuru Matsuda;
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正文语种 eng
中图分类药学;药品;
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1. RP-1776,a Novel Cyclic Peptide Produced by Streptomyces sp.,Inhibits the binding of PDGF to the Extracellular Domain of Its Receptor [J] . Shinichiro Toki, Tsutomu Agatsuma, Keiko Ochiai, The Journal of Antibiotics: An International Journal . 2001,第5期

机译：RP-1776，由链霉菌属产生的一种新型环肽，抑制PDGF与其受体的胞外域结合
2. Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor [J] . Nitin Chitranshi, Vivek Gupta, Yogita Dheer, Data in Brief . 2016,第1期

机译：环肽抑制剂与TrkB受体胞外域的分子决定因素和相互作用数据
3. Ohmyungsamycins A and B: Cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island [J] . Um S., Choi T.J., Kim H., The Journal of Organic Chemistry . 2013,第24期

机译：Ohmyungsamycins A和B：链霉菌属（Streptomyces sp。）产生的细胞毒性和抗菌性环肽。从火山岛
4. Design and synthesis of cyclic peptide antagonists intended to block coactivator binding to steroid nuclear receptors [C] . Anne-Marie Leduc, Kelli S.Bramlett, Thomas P.Burris, the International Peptide Symposium . 2001

机译：旨在阻断与类固醇核受体结合的循环肽拮抗剂的设计和合成
5. Design and synthesis of cyclic peptide antagonists intended to block coactivator binding to steroid nuclear receptors. [D] . Leduc, Anne-Marie A. 2001

机译：设计和合成旨在阻止辅助激活剂与类固醇核受体结合的环状肽拮抗剂。
6. Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor [O] . Nitin Chitranshi, Vivek Gupta, Yogita Dheer, 2016

机译：环肽抑制剂与TrkB受体胞外域的分子决定因素和相互作用数据
7. Molecular determinants and interaction data of cyclic peptide inhibitor with the extracellular domain of TrkB receptor [O] . Chitranshi, Nitin, Gupta, Vivek, Dheer, Yogita, 2016

机译：环肽抑制剂与TrkB受体胞外域的分子决定因素和相互作用数据

RP-1776,a Novel Cyclic Peptide Produced by Streptomyces sp.,Inhibits the binding of PDGF to the Extracellular Domain of Its Receptor

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