Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora II. Determination of Chemical Structure

Yasuaki Esumi; Yoshikatsu Suzuki; Masakazu Uramoto; Ken-Ichi Kimura; Masaaki Goto; Makoto Yoshihama; Teruo Ichikawa

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Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora II. Determination of Chemical Structure

机译：Propeptin，一种由微双孢菌II产生的脯氨酰内肽酶的新抑制剂。化学结构的确定

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The structure of propeptin, a new inhibitor of proly endopeptidase isolated from Microbispora sp. SNA-115 , was determined.FAB/MS. Edman degradation and amino acid analysis revealed propeptin to be a cyclin polypeptide consisting of 19 common L-amino acids.By FAB/MS and protein chemical methods , the primary sequence of propeptin was determined to be Gly~1-Tyr-Pro-Trp-Asp-Arg-Asp~9-Leu-Phe-Gly-Gly-His-Thr-Phe-Ile-Ser-Pro~(19), which cyclizes between the #beta#-carboxyl group of Asp~9 and the #alpha#-amino group of Gly~1

机译：Proeptin的结构，Proepteptin是一种从Microbispora sp。中分离出来的新型内肽酶抑制剂。测定了SNA-115。FAB/ MS。埃德曼（Edman）降解和氨基酸分析表明，前肽素是一种由19种常见L-氨基酸组成的细胞周期素多肽。通过FAB / MS和蛋白质化学方法，确定前肽的主要序列为Gly〜1-Tyr-Pro-Trp-。 Asp-Arg-Asp〜9-Leu-Phe-Gly-Gly-His-Thr-Phe-Ile-Ser-Pro〜（19），可在Asp〜9的＃beta＃-羧基与#alpha之间循环Gly〜1的＃-氨基

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《The Journal of Antibiotics: An International Journal》 |2002年第3期|共5页
作者
Yasuaki Esumi; Yoshikatsu Suzuki; Masakazu Uramoto; Ken-Ichi Kimura; Masaaki Goto; Makoto Yoshihama; Teruo Ichikawa;
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正文语种 eng
中图分类药学;药品;
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1. Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora II. Determination of Chemical Structure [J] . Yasuaki Esumi, Yoshikatsu Suzuki, Masakazu Uramoto, The Journal of Antibiotics: An International Journal . 2002,第3期

机译：Propeptin，一种由微双孢菌II产生的脯氨酰内肽酶的新抑制剂。化学结构的确定
2. Terreulactones A, B, C, and D: Novel Acetylcholinesterase Inhibitors Produced by Aspergillus terreus II. Physico-chemical Properties and Structure Determination [J] . Wong-Gon Kim, Kyung-Mi Cho, Chong-Kil Lee, The Journal of Antibiotics: An International Journal . 2003,第4期

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3. Fluostatins A and B, new inhibitors of dipeptidyl peptidase III, produced by Streptomyces sp. TA-3391 - II. Structure determination [J] . Akiyama T., Takahashi Y., Naganawa H., The Journal of Antibiotics: An International Journal . 1998,第6期

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4. Determination of Field Chemicals: Corrosion Inhibitor (CI) and Kinetic Hydrate Inhibitor (KHI) in Produced Water [C] . Iasik Riza Turkmen, Nabin Upadhyay, Samir Gharfeh International Gas Processing Symposium . 2012

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5. Biochemical characterization and structure determination of a prolyl 4-hydroxylase-like protein from Bacillus anthracis. [D] . Culpepper, Megen A. 2009

机译：炭疽芽孢杆菌脯氨酰4-羟化酶样蛋白的生化特性和结构测定。
6. Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue [O] . Lu Shan, Thomas Marti, Ludvig M. Sollid, 2004

机译：三种细菌脯氨酰内肽酶的比较生化分析：对腹腔注射的影响
7. A Prolyl Endopeptidase Inhibitor, Propeptin Production in the Various Microbispora sp. [O] . Ken-ichi Kimura, Fumiko Kanou, Makoto Yoshihama 1997

机译：脯氨酰内肽酶抑制剂，在各种Microbispora sp中产生培养。
8. Biotechnology for Producing Fuels and Chemicals from Biomass. Volume II. Fermentation Chemicals from Biomass [R] . Villet, R. 1981

机译：从生物质生产燃料和化学品的生物技术。第二卷。生物质发酵化学品

Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora II. Determination of Chemical Structure

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