An unexpected inhibitory effect of rapamycin against germination of spores of bacillus brevis strain nagano

Wan-Seop Kim; Lang Xu; Daniel Souw; Aiqi Fang; Arnold L.Demain

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An unexpected inhibitory effect of rapamycin against germination of spores of bacillus brevis strain nagano

机译：雷帕霉素对短小芽孢杆菌长野芽孢萌发的出乎意料的抑制作用

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Rapamycin is used in medicine as an immunosuppressive agent (Sirolimus; Rapamune~(TM)) although discovered as an antifungal agent. It is thought not to have antibacterial activity. Surprisingly, we found that rapamycin inhibits the germination of Bacillus brevis Nagano spores, but is inactive against Bacillus brevis Nagano vegetative cells. Surprisingly rapamycin did not show antimicrobial activity against other Bacillus strains, including other gramicidin S-producing Bacillus brevis strains such as ATCC 9999 and BI-7, whether tested as spores or vegetative cells.

机译：雷帕霉素虽然被发现是抗真菌剂，但仍在医学上用作免疫抑制剂（西罗莫司（Sirolimus; RapamuneTM））。据认为不具有抗菌活性。令人惊讶地，我们发现雷帕霉素抑制短芽孢杆菌长野芽孢的萌发，但是对短芽孢杆菌长野芽孢的营养细胞没有活性。令人惊讶的是，雷帕霉素对于其他芽孢杆菌菌株，包括其他产短杆菌肽的短杆菌芽孢杆菌，例如ATCC 9999和BI-7，无论是作为孢子还是营养细胞进行测试，均未显示出抗菌活性。

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《The Journal of Antibiotics: An International Journal》 |2002年第7期|共5页
作者
Wan-Seop Kim; Lang Xu; Daniel Souw; Aiqi Fang; Arnold L.Demain;
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中图分类药学;药品;
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1. An unexpected inhibitory effect of rapamycin against germination of spores of bacillus brevis strain nagano [J] . Wan-Seop Kim, Lang Xu, Daniel Souw, The Journal of Antibiotics: An International Journal . 2002,第7期

机译：雷帕霉素对短小芽孢杆菌长野芽孢萌发的出乎意料的抑制作用
2. Effects of Some Pesticides on Spore Germination and Larvicidal Activity of Bacillus thuringiensis var. israelensis and Bacillus sphaericus 2362 Strain [J] . Ismet Berber, Cumhur Cokmus, Ekrem Atalan Turkish journal of biology . 2004,第1期

机译：几种农药对苏云金芽孢杆菌孢子萌发和杀幼虫活性的影响以色列和球形芽孢杆菌2362菌株
3. Effects of Some Pesticides on Spore Germination and Larvicidal Activity of Bacillus thuringiensis var. israelensis and Bacillus sphaericus 2362 Strain [J] . Ismet Berber, Cumhur Cokmus, Ekrem Atalan Turkish journal of biology . 2004,第1期

机译：几种农药对苏云金芽孢杆菌孢子萌发和杀幼虫活性的影响以色列和球形芽孢杆菌2362菌株
4. The different pathways of spore germination and inactivation of Bacillus subtilis under high pressure and elevated temperatures [C] . Kai Reineke, Isabel Doehner, Daniel Baier, International congress on engineering and food . 2011

机译：高压下枯草芽孢杆菌的孢子萌发和枯灭性的不同途径和升高的温度
5. Identification of a new protein involved in Bacillus subtilis spore germination and study of its gene expression, localization and cross-linking into the spore coat. [D] . Ragkousi, Katerina. 2004

机译：鉴定一种新的参与枯草芽孢杆菌孢子萌发的蛋白质，并研究其基因表达，定位和交联到孢子皮中。
6. Germination-initiated spores of Bacillus brevis Nagano retain their resistance properties. [O] . E Daher, E Rosenberg, A L Demain 1985

机译：短芽孢杆菌长野芽孢萌发引发的孢子保留了它们的抗性。
7. Spores from mesophilic Bacillus cereus strains germinate better and grow faster in simulated gastro-intestinal conditions than spores from psychrotrophic strains. [O] . Wijnands, L M, Dufrenne, J B, Zwietering, M H, 2006

机译：在模拟胃肠道条件下，嗜温芽孢杆菌菌株的孢子比精神营养菌株的孢子发芽更好，生长更快。
8. Fluorometric Assay to Detect the Germination of Bacillus Anthracis Spores and the Germination Inhibitory Effects of Antibodies [R] . Welkos, S. L., Rea, K. M., Lee, J. S., 2003

机译：荧光检测法检测炭疽杆菌孢子萌发及抗体萌发抑制作用

An unexpected inhibitory effect of rapamycin against germination of spores of bacillus brevis strain nagano

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