A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp SANK 62799

Muramatsu Y; Ohnuki T; Ishii MM; Kizuka M; Enokita R; Miyakoshi S; Takatsu T; Inukai M

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A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp SANK 62799

机译：A-503083 A，B，E和F，链霉菌属细菌SANK 62799生产的新型细菌转位酶I抑制剂

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Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as A-503083 A, B, E and E Their structures were elucidated as 2'-O-carbamoyl derivatives of A-500359 A, B (capuramycin), E and F, respectively. A-503083 A, B, E and F inhibited bacterial phospho-N-acetylmuramyl-pentapeptide-translocase (translocase I: EC 2.7.8.13) with IC50 values of 0.024, 0.038, 0.135 and 17.9 muM, respectively.

机译：从分类为链霉菌属的菌株的培养液中分离出新型核苷抗生素。 SANK62799。该菌株产生了四种新的卡普拉霉素衍生物，分别命名为A-503083 A，B，E和E。其结构分别由A-500359 A，B（卡普拉霉素），E和F的2'-O-氨基甲酰基衍生物阐明。。 A-503083 A，B，E和F抑制细菌磷酸-N-乙酰基村mura基五肽-转位酶（转位酶I：EC 2.7.8.13），IC50值分别为0.024、0.038、0.135和17.9μM。

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来源
《The Journal of Antibiotics: An International Journal》 |2004年第10期|共8页
作者
Muramatsu Y; Ohnuki T; Ishii MM; Kizuka M; Enokita R; Miyakoshi S; Takatsu T; Inukai M;
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正文语种 eng
中图分类药学;
关键词
CAPURAMYCIN; MUREIDOMYCINS; FERMENTATION; A-500359; TAXONOMY;

机译：卡帕霉素;莫雷多霉素;发酵;A-500359;税法;

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1. A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp SANK 62799 [J] . Muramatsu Y, Ohnuki T, Ishii MM, The Journal of Antibiotics: An International Journal . 2004,第10期

机译：A-503083 A，B，E和F，链霉菌属细菌SANK 62799生产的新型细菌转位酶I抑制剂
2. A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity. [J] . Murakami R, Fujita Y, Kizuka M, The Journal of Antibiotics: An International Journal . 2008,第9期

机译：A-94964，一种由Streptomyces sp。生产的新型细菌转座酶I抑制剂。 SANK60404。I.分类学，隔离和生物活性。
3. A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation. [J] . Fujita Y, Murakami R, Muramatsu Y, The Journal of Antibiotics: An International Journal . 2008,第9期

机译：A-94964，一种由细菌链霉菌属产生的新型细菌转座酶I抑制剂。 SANK 60404。理化性质和结构阐明。
4. Inhibition effects on Escherichia coli and Staphylococcus aureus of purple pigment produced by Streptomyces sp. Dagang-2 [C] . Liu HaiJun, Zhu MiJia, Yuan ZhiMin International Conference on Energy and Environmental Protection . 2014

机译：用链霉菌Sp产生的紫色颜料的大肠杆菌和金黄色葡萄球菌的抑制作用。大港-2.
5. Studies on biocontrol of Fusarium wilt of Cajanus cajan b Paenibacillus sp. D1 and Streptomyces sp. A6 [D] . Singh, Anil Kumar. 2010

机译：Cajanus cajan b Paenibacillus sp。枯萎病的生物防治研究。 D1和链霉菌sp。 A6
6. Streptomyces sp SM01 isolated from Indian soil produces a novel antibiotic picolinamycin effective against multi drug resistant bacterial strains [O] . Pulak Kumar Maiti, Sujoy Das, Prithidipa Sahoo, -1

机译：从印度土壤中分离出的链霉菌sp01产生了一种新型的抗青霉素霉素可有效抵抗多种耐药菌株
7. A-503083 A, B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 62799 [O] . YASUNORI MURAMATSU, TAKASHI OHNUKI, MICHIKO MIYAZAWA ISHII, 2004

机译：A-503083A，B，E和F，细菌型荧光酶I的新型抑制剂，由Streptomyces SP产生。沉没62799.

A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp SANK 62799

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