Oleamycins A and B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp.

RajuR.; GromykoO.; AndriyB.; FedorenkoV.; LuzhetskyyA.; MüllerR.

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Oleamycins A and B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp.

机译：Oleamycins A和B：从陆地链霉菌属（Streptomyces sp。）分离出的新的抗菌环六肽肽。

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Menin is an essential co-factor of oncogenic MLL fusion proteins and the menin-MLL interaction is critical for development of acute leukemia in vivo. Targeting the menin-MLL interaction with small molecules represents an attractive strategy to develop new anticancer agents. Recent developments, including determination of menin crystal structure and development of potent small molecule and peptidomimetic inhibitors, demonstrate the feasibility of targeting the menin-MLL interaction. On the other hand, biochemical and structural studies revealed that MLL binds to menin in a complex bivalent mode engaging two MLL motifs, and therefore inhibition of this protein-protein interaction represents a challenge. This review summarizes the most recent achievements in targeting the menin-MLL interaction as well as discusses potential benefits of blocking menin in cancer.

机译：Menin是致癌MLL融合蛋白的重要辅助因子，而Menin-MLL相互作用对于体内急性白血病的发展至关重要。靶向与小分子的脑膜蛋白-MLL相互作用代表了开发新的抗癌药的有吸引力的策略。最近的发展，包括确定Menin晶体结构以及开发有效的小分子和拟肽抑制剂，证明了靶向Menin-MLL相互作用的可行性。另一方面，生化和结构研究表明，MLL以参与两个MLL基序的复杂的二价模式与Menin结合，因此抑制这种蛋白-蛋白相互作用是一个挑战。这篇综述总结了针对menin-MLL相互作用的最新成就，并讨论了阻断menin在癌症中的潜在益处。

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《The Journal of Antibiotics: An International Journal》 |2014年第4期|共5页
作者
RajuR.; GromykoO.; AndriyB.; FedorenkoV.; LuzhetskyyA.; MüllerR.;
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正文语种 eng
中图分类药学;
关键词
19-membered cyclic hexadepsipeptide; glycine; natural products chemistry; piperazic acid;

机译：19元环六肽;甘氨酸;天然产物化学;哌嗪酸;

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1. Oleamycins A and B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp. [J] . RajuR., GromykoO., AndriyB., The Journal of Antibiotics: An International Journal . 2014,第4期

机译：Oleamycins A和B：从陆地链霉菌属（Streptomyces sp。）分离出的新的抗菌环六肽肽。
2. NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities. [J] . Guo Z, Shen L, Ji Z, The Journal of Antibiotics: An International Journal . 2009,第4期

机译：NW-G01，一种新的环状六肽抗菌素，由链霉菌链霉菌（Streptomyces alboflavus）313生产：I.分类学，发酵，分离，理化特性和抗菌活性。
3. Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5. [J] . Abdelfattah MS Natural product research . 2009,第3期

机译：异戊二烯酮：来自陆地链霉菌属的新型抗菌芳香族聚酮化合物的分离和结构解析。例如5。
4. Synergistic Antibacterial Activities of Bioactive Compounds from Streptomyces sp. RS2 in Combination with Vancomycin against Staphylococcus aureus [C] . Nongyao Nonpanya, Suwanna Niamsanit, Kwanjai Kanokmedhakul, IEEE International Conference on Engineering Technologies and Applied Sciences . 2018

机译：链霉菌属生物活性化合物的协同抗菌活性。 RS2联合万古霉素抗金黄色葡萄球菌
5. Studies on nitrogen-containing secondary metabolites from terrestrial and marine origin: Part I. Enzymatic epoxidation of 2,5-dihydroxyacetanilide in Streptomyces sp. Part II. Synthesis of marine sponge alkaloids: Slagenins, axinohydantoins, and studies towards the pyrrolopiperazine system in the agelastatin core. [D] . Barrios Sosa, Ana Carolina. 2002

机译：陆生和海洋来源的含氮次生代谢产物的研究：第一部分。链霉菌属中2,5-二羟基乙酰苯胺的酶促环氧化。第二部分海洋海绵生物碱的合成：Slagenins，Axinohydantoins，以及在astlastatin核心中对吡咯烷哌嗪系统的研究。
6. Draft Genome Sequence of Streptomyces sp. Strain ventii Isolated from a Microbial Mat near Hydrothermal Vents within the Axial Seamount in the Pacific Ocean and Resequencing of the Type Strains Streptomyces lonarensis NCL 716 and Streptomyces bohaiensis 11A07 [O] . Rachel M. Loughran, Edward A. Mitchell, Oliver B. Vining, 2020

机译：streptomyces sp的基因组序列草案。应变Ventii从太平洋轴山内的水热通风口附近的微生物垫中分离以及菌株的Reseprying Streptomyces LeNarensis NCL 716和Streptomyces BohaieNsis 11a07
7. Kettapeptin: Isolation, Structure Elucidation and Activity of a New Hexadepsipeptide Antibiotic from a Terrestrial Streptomyces sp. [O] . Rajendra P Maskey, Serge Fotso, Madhumati Sevvana, 2006

机译：Kettapeptin：从陆生链霉菌SP中的新六己二肽抗生素的分离，结构阐明和活性。

Oleamycins A and B: New antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp.

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