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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Inhibition of indoleamine 2,3-dioxygenase by thielavin derivatives from a soil fungus, Coniochaeta sp. 10F058
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Inhibition of indoleamine 2,3-dioxygenase by thielavin derivatives from a soil fungus, Coniochaeta sp. 10F058

机译：土壤真菌Coniochaeta sp。的硫磺素衍生物对吲哚胺2,3-二加氧酶的抑制作用。 10F058

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The putative tumor suppressor protein spinophilin has been recently involved in the pathogenesis of lung, liver, and other types of cancer. Previous studies also indicate that a loss of spinophilin in combination with functional impairment of p53 drives tumor progression. To date, no data exist about the role of spinophilin in head and neck squamous cell carcinoma (HNSCC). In the present study, we evaluated spinophilin and p53 expression by immunohistochemistry in 85 patients with nonmetastatic HNSCC. Kaplan-Meier curves and multivariate Cox proportional models were used to define the prognostic relevance of spinophilin for patients with HNSCC. Overall, immunoreactivity for spinophilin was reduced in 40 tumors (47%). Nine cases (10.5%) showed complete loss of spinophilin. Kaplan-Meier curve analysis demonstrated that reduced spinophilin expression is associated with poor overall survival (P =.022). Concomitant analysis of spinophilin and p53 further showed that patients with reduced spinophilin expression and nuclear p53 staining have a significantly decreased overall survival (hazard ratio, 1.96; 95% confidence interval, 1.06-3.61; P =.030). In conclusion, the combination of reduced spinophilin expression and nuclear p53 staining indicates a poor prognosis in HNSCC patients. Based on our results, spinophilin might play a previously unrecognized role in the pathogenesis of HNSCC.
机译：推定的肿瘤抑制蛋白Spinophilin最近已参与肺癌，肝癌和其他类型癌症的发病机理。先前的研究还表明，旋转蛋白的丧失与p53的功能损害相结合会驱动肿瘤的进展。迄今为止，尚无关于亲脂蛋白在头颈部鳞状细胞癌（HNSCC）中的作用的数据。在本研究中，我们通过免疫组织化学评估了85例非转移性HNSCC患者中的亲脂蛋白和p53表达。使用Kaplan-Meier曲线和多变量Cox比例模型确定Spinophilin对HNSCC患者的预后相关性。总体而言，在40个肿瘤中，亲脂蛋白的免疫反应性降低了（47％）。 9例（10.5％）显示出亲脂蛋白完全丧失。 Kaplan-Meier曲线分析表明，亲脂蛋白表达降低与总生存期差有关（P = .022）。亲脂蛋白和p53的伴随分析进一步表明，亲脂蛋白表达降低和p53核染色的患者总体生存率显着降低（危险比1.96; 95％置信区间1.06-3.61; P = 0.030）。总之，亲和蛋白表达降低和核p53染色的结合表明HNSCC患者的预后较差。根据我们的结果，亲脂蛋白可能在HNSCC的发病机理中发挥了以前未被认识的作用。

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