Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp MK932-CF8

Yamazaki Yohko; Someno Tetsuya; Igarashi Masayuki; Kinoshita Naoko; Hatano Masaki; Kawada Manabu; Momose Isao; Nomoto Akio

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Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp MK932-CF8

机译：链霉菌属MK932-CF8生产的新型抗前列腺癌药物Androprostamines A和B

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Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes.

机译：在前列腺癌的所有临床状态中，雄激素受体（AR）是经过验证的靶标。从链霉菌中分离出新的雄激素受体抑制剂雄前列腺素A和B。 MK932-CF8。它们的结构通过光谱分析，降解研究和合成来确定。 Androprostamines对人前列腺癌细胞的雄激素依赖性生长表现出有效的抑制作用，而没有细胞毒性，并抑制了雄激素诱导的AR调控基因的表达。

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《The Journal of Antibiotics: An International Journal》 |2015年第4期|共7页
作者
Yamazaki Yohko; Someno Tetsuya; Igarashi Masayuki; Kinoshita Naoko; Hatano Masaki; Kawada Manabu; Momose Isao; Nomoto Akio;
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正文语种 eng
中图分类药学;
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1. Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp MK932-CF8 [J] . Yamazaki Yohko, Someno Tetsuya, Igarashi Masayuki, The Journal of Antibiotics: An International Journal . 2015,第4期

机译：链霉菌属MK932-CF8生产的新型抗前列腺癌药物Androprostamines A和B
2. Steffimycin E, a new anti-mycobacterial agent against Mycobacterium avium complex, produced by Streptomyces sp. OPMA02852 [J] . Koyama Nobuhiro, Shigeno Satoru, Kanamoto Akihiko, The Journal of Antibiotics: An International Journal . 2020,第8期

机译：Steffimycin E，一种针对分枝杆菌复合物的新的抗分枝杆菌剂，由Streptomyces Sp产生。 OPMA02852.
3. YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001 [J] . Yamamoto Kai, Futamura Yushi, Uson-Lopez Rachael A., The Journal of Antibiotics: An International Journal . 2019,第12期

机译：Yo-001a是一种由Streptomyces SP产生的新的抗真菌剂。 YO15-A001.
4. Inhibition effects on Escherichia coli and Staphylococcus aureus of purple pigment produced by Streptomyces sp. Dagang-2 [C] . Liu HaiJun, Zhu MiJia, Yuan ZhiMin International Conference on Energy and Environmental Protection . 2014

机译：用链霉菌Sp产生的紫色颜料的大肠杆菌和金黄色葡萄球菌的抑制作用。大港-2.
5. Studies on the Potential of 3-O-Substituted-flavonols as Anti-Prostate Cancer Agents. [D] . Li, Xiang. 2017

机译：3-O取代的黄酮醇作为抗前列腺癌药物的潜力研究。
6. Analysis of the complete genome sequence of a marine-derived strain Streptomyces sp. S063 CGMCC 14582 reveals its biosynthetic potential to produce novel anti-complement agents and peptides [O] . Liang-Yu Chen, Hao-Tian Cui, Chun Su, -1

机译：海洋来源的链霉菌菌株的完整基因组序列分析。 S063 CGMCC 14582揭示了其生物合成潜力可产生新型的抗补体剂和肽
7. Peer Review #1 of "Analysis of the complete genome sequence of a marine-derived strain Streptomyces sp. S063 CGMCC 14582 reveals its biosynthetic potential to produce novel anti-complement agents and peptides (v0.1)" [O] . 2019

机译：同行评论“海洋衍生菌株STRESTOMYCES SP的完整基因组序列分析”＃1。S063 CGMCC 14582揭示了生产新型抗补体剂和肽（V0.1）的生物合成潜力。
8. Anibamine and its Analogues as Novel Anti-Prostate Cancer Agents [R] . Zhang, Y. 2009

机译：anibamine及其类似物作为新型抗前列腺癌药物

Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp MK932-CF8

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