YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

Yamamoto Kai; Futamura Yushi; Uson-Lopez Rachael A.; Aono Harumi; Shimizu Takeshi; Osada Hiroyuki

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YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

机译：Yo-001a是一种由Streptomyces SP产生的新的抗真菌剂。 YO15-A001.

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A new antifungal compound YO-001A was found from the culture broth of Streptomyces sp. YO15-A001, which was isolated from a soil sample collected in Toyama Prefecture. YO-001A was identified through morphological changes-based screening of the rice blast fungus, Pyricularia oryzae (P. oryzae). YO-001A is a new 26-membered macrolide of the oligomycin family, which exhibits potent antifungal activity against P. oryzae with an IC50 of 0.012 mu M by disrupting mitochondrial respiration via inhibition of the FOF1-ATPase activity.

机译：从Streptomyces sp的培养液中发现了一种新的抗真菌化合物yo-001a。 YO15-A001，从富山县收集的土壤样本中分离出来。通过基于形态学的变化的稻瘟病真菌筛查鉴定了YO-001A，Pyricularia Oryzae（P. Oryzae）。 YO-001A是寡霉素家族的新的26元大环，通过抑制FOF1-ATP酶活性破坏线粒体呼吸来表现出对P. Oryzae的有效的抗真菌活性。

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《The Journal of Antibiotics: An International Journal》 |2019年第12期|共5页
作者
Yamamoto Kai; Futamura Yushi; Uson-Lopez Rachael A.; Aono Harumi; Shimizu Takeshi; Osada Hiroyuki;
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RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

RIKEN Chem Biol Res Grp Ctr Sustainable Resource Sci 2-1 Hirosawa Wako Saitama 3510198 Japan;

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正文语种 eng
中图分类药学;
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1. YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001 [J] . Yamamoto Kai, Futamura Yushi, Uson-Lopez Rachael A., The Journal of Antibiotics: An International Journal . 2019,第12期

机译：Yo-001a是一种由Streptomyces SP产生的新的抗真菌剂。 YO15-A001.
2. Isolation, Identification and Optimal Culture Conditions of Streptomyces albidoflavus C247 Producing Antifungal Agents against Rhizoctonia solani AG2-2 [J] . Islam Md. Rezuanul, Jeong Yong Tae, Ryu Yeon Ju, Mycobiology . 2009,第2期

机译：产链霉菌C247产抗根瘤菌AG2-2抗真菌剂的分离，鉴定及最佳培养条件
3. Isolation, Identification and Optimal Culture Conditions of Streptomyces albidoflavus C247 Producing Antifungal Agents against Rhizoctonia solani AG2-2 [J] . Islam Md. Rezuanul, Jeong Yong Tae, Ryu Yeon Ju, Mycobiology . 2009,第2期

机译：产链霉菌S247 solani根瘤菌AG2-2的分离，鉴定和最佳培养条件
4. Antifungal Agent Produced by Rhizosphere Moulds from Lycopersicon esculentum (Mill) Against Fusarium oxysporum f. sp. lycopersici. [C] . Riajeng Kristiana, Suciatmih, Wibowo Mangunwardoyo International Symposium on Current Progress in Mathematics and Sciences . 2016

机译：由来自Lycopersicon Esculentum（Mill）的根际模具产生的抗真菌剂对抗Fusarium oxysporum f。 sp。 Lycopersici。
5. Biological and chemical studies on the antifungal compounds produced by Streptomyces violaceusniger YCED-9. [D] . Trejo-Estrada, Sergio Ruben. 1997

机译：紫色链霉菌YCED-9产生的抗真菌化合物的生物化学研究。
6. Isolation Identification and Optimal Culture Conditions of Streptomyces albidoflavus C247 Producing Antifungal Agents against Rhizoctonia solani AG2-2 [O] . Md. Rezuanul Islam, Yong Tae Jeong, Yeon Ju Ryu, 2009

机译：产链霉菌C247产抗根瘤菌AG2-2抗真菌剂的分离鉴定及最佳培养条件
7. Peer Review #1 of "Analysis of the complete genome sequence of a marine-derived strain Streptomyces sp. S063 CGMCC 14582 reveals its biosynthetic potential to produce novel anti-complement agents and peptides (v0.1)" [O] . 2019

机译：同行评论“海洋衍生菌株STRESTOMYCES SP的完整基因组序列分析”＃1。S063 CGMCC 14582揭示了生产新型抗补体剂和肽（V0.1）的生物合成潜力。

YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001

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