Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus

SHOHEI SAKUDA; HIROYUKI IKEDA; TAKEFUMI NAKAMURA; RYU KAWACHI; TATSUHIKO KONDO; MAKOTO ONO; MASARU SAKURADA; HIROYUKI INAGAKI; RYOUICHI ITO; HIROMICHI NAGASAWA

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus

【24h】

Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus

机译：对寄生曲霉中的黄曲霉毒素生产具有高度特异性抑制活性的Blasticidin A衍生物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Blasticidin A (1),an antibiotic,has strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus.We prepared some derivatives of 1 and examined their biological activities.Among them,derivatives 3 and 4 without the tetramic acid moiety of 1 maintained inhibitory activity toward aflatoxin production,but did not show antifungal activity of or toxicity.RT-PCR experiments indicated that derivatives 3 and 4 as well as 1 significantly resuced the expression of genes encoding aflatoxin biosynthetic enzymes (pksA,ver-1 and omtA) and a regulatory gene(aflR) in A.parasiticus.These results suggested that derivatives 3 and 4 can inhibit aflatoxin production nore specifically than 1 by inhibiting an early step prior to the expression of aflR in the pathway of aflatoxin biosynthesis.

机译：杀虫素A（1）对寄生虫曲霉产生的黄曲霉毒素具有很强的抑制活性。我们制备了1的一些衍生物并检查了它们的生物学活性。其中，没有1的四酸部分的衍生物3和4保持对1的抑制活性。 RT-PCR实验表明，衍生物3和4以及1显着恢复了编码黄曲霉毒素生物合成酶的基因（pksA，ver-1和omtA）和调控基因的表达。这些结果表明，衍生物3和4通过抑制黄曲霉毒素生物合成途径中aflR表达之前的早期步骤，可以抑制黄曲霉毒素的产生而不是1抑制黄曲霉毒素的产生。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2000年第12期|共7页
作者
SHOHEI SAKUDA; HIROYUKI IKEDA; TAKEFUMI NAKAMURA; RYU KAWACHI; TATSUHIKO KONDO; MAKOTO ONO; MASARU SAKURADA; HIROYUKI INAGAKI; RYOUICHI ITO; HIROMICHI NAGASAWA;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;药品;
关键词

相似文献

外文文献
中文文献
专利

1. Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus [J] . SHOHEI SAKUDA, HIROYUKI IKEDA, TAKEFUMI NAKAMURA, The Journal of Antibiotics: An International Journal . 2000,第12期

机译：对寄生曲霉中的黄曲霉毒素生产具有高度特异性抑制活性的Blasticidin A衍生物
2. New Metabolic Pathway for Converting Blasticidin S in Aspergillus flavus and Inhibitory Activity of Aflatoxin Production by Blasticidin S Metabolites [J] . Tomoya Yoshinari, Shohei Sakuda, Maiko Watanabe Journal of Agricultural and Food Chemistry . 2013,第33期

机译：黄曲霉中转化菌素S的新代谢途径和对由菌素S代谢产物产生黄曲霉毒素的抑制活性
3. Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus [J] . SHOHEI SAKUDA, MAKOTO ONO, HIROYUKI IKEDA, The Journal of Antibiotics: An International Journal . 2000,第11期

机译：弹性蛋白A作为寄生曲霉产生黄曲霉毒素的抑制剂
4. Fungicide resistance and aflatoxin production; the effect of resistance mutations to triazoles, phenylpyrroles and anilinopyrimidine fungicides on aflatoxigenic ability of Aspergillu s parasiticus [C] . E G Doukas, A N Markoglou, B N Ziogas International Symposium of the British Crop Protection Council . 2007

机译：杀菌剂抗性和黄曲霉毒素生产;抗血栓制，苯基吡咯和苯胺嘧啶杀菌剂对叶氏菌寄生虫的黄毒性能力的影响
5. Effect of modified atmosphere packaging on the growth and aflatoxin production by Aspergillus flavus and Aspergillus parasiticus under tropical environmental storage conditions. [D] . Ellis, William Otoo. 1993

机译：气调包装对热带环境储存条件下黄曲霉和寄生曲霉的生长和黄曲霉毒素产生的影响。
6. Inhibitory Activities of Blasticidin S Derivatives on Aflatoxin Production by Aspergillus Flavus [O] . Tomoya Yoshinari, Yoshiko Sugita-Konishi, Takahiro Ohnishi, 2017

机译：弹性蛋白S衍生物对黄曲霉产生黄曲霉毒素的抑制活性
7. Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus. [O] . SHOHEI SAKUDA, MAKOTO ONO, HIROYUKI IKEDA, 2000

机译：Blasterastidin A作为Aspergillus Parasiticus的黄曲霉毒素抑制剂。

Blasticidin A Derivatives with Highly Specific Inhibitory Activity toward Aflatoxin Production in Aspergillus parasiticus

摘要

著录项

相似文献

相关主题

期刊订阅