Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

Fang AQ.; Demain AL.; Wong GK.

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Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

机译：共同产生的elaiophylin和nigericin增强雷帕霉素的抗真菌活性

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Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans. [References: 21]

机译：吸水链霉菌ATCC 29253产生雷帕霉素，弹性蛋白和黑霉素。尽管弹性蛋白没有抗白色念珠菌ATCC 11651的活性，但它显着增强了雷帕霉素的抗真菌活性。 Nigericin本身仅具有弱活性，但也可增强雷帕霉素的作用。令人惊讶的是，弹性蛋白没有增强白念珠菌上的尼日利亚霉素活性。 [参考：21]

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《The Journal of Antibiotics: An International Journal》 |2000年第2期|共5页
作者
Fang AQ.; Demain AL.; Wong GK.;
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原文格式 PDF
正文语种 eng
中图分类药学;药品;
关键词
Streptomyces-hygroscopicus; Biological-activities; Shikimic acid; Biosynthesis; Disruption; Atcc-29253; Strain;

机译：吸水链霉菌;生物活性;Shi草酸;生物合成;破坏;Atcc-29253;菌株;

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1. Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin [J] . Fang AQ., Demain AL., Wong GK. The Journal of Antibiotics: An International Journal . 2000,第2期

机译：共同产生的elaiophylin和nigericin增强雷帕霉素的抗真菌活性
2. Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor [J] . Robert J. Bastidas, Cecelia A. Shertz, Soo Chan Lee, Eukaryotic cell . 2012,第3期

机译：雷帕霉素通过FKBP12依赖的Tor抑制作用对Mucor circinelloides的体外和体内抗真菌活性
3. Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin [J] . Wong GK., Kojima I., Demain AL., The Journal of Antibiotics: An International Journal . 1998,第5期

机译：雷帕霉素及其衍生物，前雷帕霉素，32-去甲基雷帕霉素和32-去甲氧基雷帕霉素的抗真菌活性
4. 6 Radiation-Induced Enhancement of antifungal Activity of CHitosan on Fruit-Spoiling Fungi during Postharvest Storage [C] . Tran Bang Diep, Nguyen Duy Lam, Tran Minh Quynh, Takasaki symposium on radiation processing of natural polymers . 2001

机译：6辐射诱导壳聚糖对果实贮藏期间壳聚糖抗真菌活性的增强
5. Enhancement of Drug Release and Antifungal Activity of Econazole from Dermatological Formulations Using Reduced Level of Drug. [D] . Aguirre, Elizabeth T. 2017

机译：使用降低的药物水平增强皮肤科制剂中益康唑的药物释放和抗真菌活性。
6. Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin [O] . Esteban A. Orellana, Ahmed M. Abdelaal, Loganathan Rangasamy, 2019

机译：通过增加尼日菌介导的内体释放来增强MicroRNA活性
7. Enhancing microRNA activity through increased endosomal release mediated by nigericin [O] . Esteban A. Orellana, Loganathan Rangasamy, Srinivasarao Tenneti, 2018

机译：通过增加Nigericin介导的内体释放来提高MicroRNA活性

Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

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