THE SYNTHESIS AND ANTIFUNGAL ACTIVITY OF N-ALKYLATED ANALOGS OF ECHINOCANDIN B

Jamison JA.; Rodriguez MJ.; Zeckner DJ.

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THE SYNTHESIS AND ANTIFUNGAL ACTIVITY OF N-ALKYLATED ANALOGS OF ECHINOCANDIN B

机译：棘皮生物碱B的N-烷基化类似物的合成及其抗真菌活性

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The synthesis and biological activity of a series of N-alkylated derivatives of echinocandin B are described and compared with the N-acylated analogs. The linear, rigid geometry of the side chain that was essential to improve the antifungal potency of the N-acylated series gave similar in vitro results with the N-alkylated derivatives. However the slight structural variation forfeited all in vivo activity. [References: 8]

机译：描述了棘皮菌素B的一系列N-烷基化衍生物的合成和生物活性，并与N-酰化类似物进行了比较。对于提高N-酰化系列的抗真菌效力至关重要的侧链的线性，刚性几何结构，在N-烷基化衍生物的作用下获得了相似的体外结果。然而，轻微的结构变化丧失了所有体内活性。 [参考：8]

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《The Journal of Antibiotics: An International Journal》 |1997年第7期|共5页
作者
Jamison JA.; Rodriguez MJ.; Zeckner DJ.;
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正文语种 eng
中图分类药学;药品;
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1. THE SYNTHESIS AND ANTIFUNGAL ACTIVITY OF N-ALKYLATED ANALOGS OF ECHINOCANDIN B [J] . Jamison JA., Rodriguez MJ., Zeckner DJ. The Journal of Antibiotics: An International Journal . 1997,第7期

机译：棘皮生物碱B的N-烷基化类似物的合成及其抗真菌活性
2. N-alkylated thiazolidine-2,4-dione analogs as PTP1B inhibitors: synthesis, biological activity, and docking studies [J] . Mahapatra Manoj K., Kumar Rajnish, Kumar Manoj Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2017,第6期

机译：作为PTP1B抑制剂的N-烷基化噻唑烷-2,4-二酮类似物：合成，生物活性和对接研究
3. Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition [J] . MorikawaH., TomishimaM., KayakiriN., Bioorganic and Medicinal Chemistry Letters . 2014,第4期

机译：具有强效曲霉菌生长抑制作用的新型棘皮菌素ASP9726的合成及抑菌活性
4. SYNTHESIS AND ANTIFUNGAL ACTIVITY EVALUATION OF NEW BENZIMIDAZOLE-TRIAZOLE DERIVATIVES AS POTENTIAL ERGESTEROL BIOSYNTHESIS INHIBITORS USING LC-MS/MS [C] . Nafiz Oncu Can, Ulviye Acar Cevik, Begum Nurpelin Saglik, International Mass Spectrometry Conference . 2018

机译：新型苯并咪唑 - 三唑衍生物作为使用LC-MS / MS的潜在伊代甲生物合成抑制剂的合成与抗真菌活性评价
5. Total synthesis and structure-activity relationship studies of antifungal peptidyl nucleoside antibiotics. [D] . Stauffer, Christina S. 2006

机译：抗真菌肽基核苷抗生素的全合成及其构效关系研究。
6. Novel Cell Wall Antifungals Reveal a Special Synergistic Activity in pbr1 Mutants Resistant to the Glucan Synthesis Antifungals Papulacandins and Echinocandins [O] . Rodrigo Berzaghi, Attila Agócs, María A. Curto, -1

机译：新型细胞壁抗真菌剂在抗葡聚糖合成抗真菌剂Papulacandins和Echinocandins的pbr1突变体中显示出特殊的协同活性。
7. Novel Cell Wall Antifungals Reveal a Special Synergistic Activity in pbr1 Mutants Resistant to the Glucan Synthesis Antifungals Papulacandins and Echinocandins [O] . Rodrigo Berzaghi, Attila Agócs, María A. Curto, 2019

机译：新型细胞壁抗菌揭示了PBR1突变体的特殊协同活性，抗葡聚糖合成抗真菌粉底花环蛋白和echinocandins

THE SYNTHESIS AND ANTIFUNGAL ACTIVITY OF N-ALKYLATED ANALOGS OF ECHINOCANDIN B

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