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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Promising lead compounds for novel antiprotozoals
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Promising lead compounds for novel antiprotozoals

机译：新型抗原生动物的有前途的先导化合物

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摘要

Malaria and human African trypanosomiasis (HAT), also known as sleeping sickness, are devastating diseases caused by infection with the protozoan parasites of the Plasmodia and Trypanosoma genera, respectively. The diseases infect millions of people. HAT, caused by infection with Trypanosoma brucei, is a complex disease and represents a major cause of morbidity and mortality in sub-Saharan Africa, where it is endemic and an estimated 70 million people are at risk of contracting it. Several epidemics of HAT occurred during the last century, but a combination of vector control, disease surveillance and early drug treatment of those infected caused the disease to almost disappear by the mid-1960s. Over the following 2-3 decades the disease re-emerged, but recent control efforts have again reduced its incidence, annual cases totaling an estimated 50 000-70 000. HAT has two distinct forms (gambiense and rhodesiense) depending on the parasite involved, each form having two specific stages. HAT is fatal if left untreated, with treatment depending on the stage of the disease.
机译：疟疾和人类非洲锥虫病（HAT）也称为昏睡病，是分别由疟原虫和锥虫属的原生动物寄生虫感染引起的破坏性疾病。这些疾病感染了数百万人。由布鲁氏锥虫感染引起的HAT是一种复杂的疾病，是撒哈拉以南非洲地区发病和死亡的主要原因，该地区是地方病，估计有7000万人感染该病。上个世纪发生了HAT的几种流行病，但病媒控制，疾病监测和对受感染者的早期药物治疗相结合，导致该病在1960年代中期几乎消失。在接下来的2-3年中，该疾病再次出现，但是最近的控制工作再次降低了其发病率，每年的病例总数估计为5万至7万。根据所涉及的寄生虫，HAT有两种截然不同的形式（冈比亚和罗氏杆菌），每种形式都有两个特定阶段。如果不及时治疗，HAT将会致命，具体取决于疾病的阶段。

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