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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Mutant prevention concentration of tigecycline for carbapenem-susceptible and -resistant Acinetobacter baumannii.
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Mutant prevention concentration of tigecycline for carbapenem-susceptible and -resistant Acinetobacter baumannii.

机译：替加环素对碳青霉烯易感和耐药鲍曼不动杆菌的突变体预防浓度。

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摘要

Acinetobacter baumannii has become a serious nosocomial pathogen, particularly with cases of ventilator-associated pneumonia and bacter-aemia.1 In recent years, many outbreaks of nosocomial infections caused by carbapenem-resistant A. baumannii have been reported.2,3 These carbapenem-resistant isolates are often resistant to multiple agents, such as cephalosporins, fluoroquinolones, aminoglycosides, tetracyclines and sulbactam.2,3 Carbapenems once had a crucial role in the management of serious nosocomial A. baumannii infections. Unfortunately, the prevalence of carbapenem-resistant isolates appears to be increasing. In China, the rate of carbapenem-resistance in A. baumannii isolates was 40-60% in 2005.4 These features make A. baumannii infections very difficult to treat as options are limited. A new broad-spectrum glycylcycline, tigecycline, shows good in vitro activity against A. baumannii5,6 and is now considered a good treatment option for multidrug-resistant A. baumannii infections.7,8 However, tigecycline-resistant A. baumannii has been observed after tigecycline treatment of A. baumannii infections.7"9 Whether tigecycline is particularly prone to emergence of resistance with A. baumannii is unknown.
机译：鲍曼不动杆菌已成为严重的医院病原体，尤其是在呼吸机相关性肺炎和细菌性贫血的情况下。1近年来，已报道了许多由耐碳青霉烯的鲍曼不动杆菌引起的医院内感染暴发。2,3这些碳青霉烯抗药性分离株通常对多种药物具有抗性，例如头孢菌素，氟喹诺酮类，氨基糖苷类，四环素类和舒巴坦[2,3]。碳青霉烯曾经在严重的医院内鲍曼不动杆菌感染的管理中起着至关重要的作用。不幸的是，对碳青霉烯耐药的分离株的流行似乎正在增加。在中国，2005年鲍曼不动杆菌分离株对碳青霉烯的耐药率为40-60％。4这些特征使得鲍曼不动杆菌的感染由于选择有限而很难治疗。一种新型的广谱甘氨酰环素tigecycline对鲍曼不动杆菌具有良好的体外活性[5,6]，现在被认为是对多重耐药性鲍曼不动杆菌感染的良好治疗选择[7,8]。替加环素治疗鲍曼不动杆菌感染后观察到。7“ 9替加环素是否特别容易出现鲍曼不动杆菌耐药性。

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