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首页> 外文期刊>The Journal of Antibiotics: An International Journal >NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy.
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NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy.

机译：peplomycin在水溶液中的NMR研究。借助二维光谱对共振进行分配。

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摘要

(1)H-NMR spectra of peplomycin (PEP) recorded at 400 and, for the first time, 900 MHz at 2 degrees C were examined. All the spin systems in the PEP molecule were identified through 2D NMR spectroscopy. The use of NMR spectroscopy allowed the unambiguous assignment of 62 protons, generating 47 non-exchangeable and 15 exchangeable signals. The analysis of the signals observed in 2D-NOE spectra indicates that PEP exhibits an extended conformation at 2 degrees C. A comparison between the solution conformation of apo-PEP and the solution structure of HOO-Co(III)-PEP indicates that the overall structure of apo-PEP is extended in solution, but exhibiting a conformation of the bithiazole (B)-sulfonium (S) unit similar to that of HOO-Co(III)-PEP. The present investigation represents the initial stage of an NMR study of the solution conformation and dynamics of PEP, its derivatives, its metal complexes and the interactions of metallo-PEPs with their target DNA.
机译：考察了在2摄氏度下400倍首次记录的peplomycin（PEP）的1 H-NMR谱图。通过2D NMR光谱鉴定了PEP分子中的所有自旋系统。 NMR光谱的使用可以明确分配62个质子，产生47个不可交换的信号和15个可交换的信号。对在2D-NOE光谱中观察到的信号的分析表明，PEP在2摄氏度时呈现出扩展的构象。apo-PEP的溶液构象与HOO-Co（III）-PEP的溶液结构之间的比较表明，整体载脂蛋白-PEP的结构在溶液中延伸，但表现出类似于HOO-Co（III）-PEP的苄基唑（B）-ulf（S）单元的构象。本研究代表了PEP，其衍生物，其金属配合物以及金属PEP与目标DNA相互作用的溶液构象和动力学的NMR研究的初期阶段。

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