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首页> 外文期刊>The Journal of Antibiotics: An International Journal >NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy.
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NMR study of peplomycin in aqueous solution. Assignment of resonances by means of two-dimensional spectroscopy.

机译：水溶液中Peplomycin的NMR研究。 通过二维光谱分配共振。

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摘要

(1)H-NMR spectra of peplomycin (PEP) recorded at 400 and, for the first time, 900 MHz at 2 degrees C were examined. All the spin systems in the PEP molecule were identified through 2D NMR spectroscopy. The use of NMR spectroscopy allowed the unambiguous assignment of 62 protons, generating 47 non-exchangeable and 15 exchangeable signals. The analysis of the signals observed in 2D-NOE spectra indicates that PEP exhibits an extended conformation at 2 degrees C. A comparison between the solution conformation of apo-PEP and the solution structure of HOO-Co(III)-PEP indicates that the overall structure of apo-PEP is extended in solution, but exhibiting a conformation of the bithiazole (B)-sulfonium (S) unit similar to that of HOO-Co(III)-PEP. The present investigation represents the initial stage of an NMR study of the solution conformation and dynamics of PEP, its derivatives, its metal complexes and the interactions of metallo-PEPs with their target DNA.
机译：（1）在400℃下记录的皮霉素（PEP）的H-NMR光谱，并在2℃下首次进行900MHz。 通过2D NMR光谱鉴定PEP分子中的所有旋转系统。 使用NMR光谱允许毫不含糊的62质子分配，产生47个不可交换的和15个可交换信号。 在2D-NOE光谱中观察到的信号的分析表明，PEP在2摄氏度下表现出延伸构象。APO-PEP和HOO-CO（III）-PEP的溶液结构之间的溶液构象之间的比较表明整体而言 APO-PEP的结构在溶液中延伸，但表现出类似于HOO-CO（III）-PEP的二唑（B）锍（S）单元的构象。 本研究代表了智商溶液综合和动态的NMR研究的初始阶段，其衍生物，其金属络合物与金属肽与其靶DNA的相互作用。

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