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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters.
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Giant linear plasmids in Streptomyces: a treasure trove of antibiotic biosynthetic clusters.

机译:链霉菌中的巨型线性质粒:抗生素生物合成簇的宝库。

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摘要

Many giant linear plasmids have been isolated from Streptomyces by using pulsed-field gel electrophoresis and some of them were found to carry an antibiotic biosynthetic cluster(s); SCP1 carries biosynthetic genes for methylenomycin, pSLA2-L for lankacidin and lankamycin, and pKSL for lasalocid and echinomycin. Accumulated data suggest that giant linear plasmids have played critical roles in genome evolution and horizontal transfer of secondary metabolism. In this review, I summarize typical examples of giant linear plasmids whose involvement in antibiotic production has been studied in some detail, emphasizing their finding processes and interaction with the host chromosomes. A hypothesis on horizontal transfer of secondary metabolism involving giant linear plasmids is proposed at the end.
机译:通过使用脉冲场凝胶电泳从链霉菌中分离出许多巨大的线性质粒,发现其中一些带有抗生素生物合成簇。 SCP1携带甲基合成霉素的生物合成基因,lankacidin和lankamycin的pSLA2-L,以及拉沙菌素和棘霉素的pKSL。积累的数据表明,巨大的线性质粒在基因组进化和次级代谢的水平转移中发挥了关键作用。在这篇综述中,我总结了一些巨型线性质粒的典型例子,这些质粒已详细研究了其参与抗生素生产的过程,强调了它们的发现过程以及与宿主染色体的相互作用。最后提出了关于涉及巨型线性质粒的次级代谢水平转移的假说。

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