New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.

Stodulkova E; Kuzma M; Hench IB; Cerny J; Kralova J; Novak P; Chudickova M; Savic M; Djokic L; Vasiljevic B; Flieger M

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New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.

机译：杜伦链霉菌的深层培养产生了新的多烯大环内酯类。

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A new polyene macrolide family, closely related to the pentaene macrolide antibiotic roflamycoin, was isolated from the both fermentation broth and biomass of Streptomyces durmitorensis wild-type strain MS405. The main compound was identified by NMR and Fourier transform ion cyclotron resonance mass spectrometry as 32,33-didehydroroflamycoin (1; DDHR). Additional four structurally related compounds were determined solely by MS analysis. DDHR induces cell death by apoptosis in various cancer cell lines as demonstrated by DNA fragmentation. Striking feature of DDHR is its internal fluorescence allowing visualization of labeled plasma membranes and internal membrane structures.

机译：从杜氏链霉菌野生型菌株MS405的发酵液和生物量中分离出与五烯大环内酯类抗生素roflamycoin密切相关的新的多烯大环内酯类。通过NMR和傅立叶变换离子回旋共振质谱法鉴定出主要化合物为32，33-二氢氢化弗罗西币（1; DDHR）。仅通过MS分析即可确定另外四个与结构相关的化合物。如DNA片段所示，DDHR通过各种癌细胞系的凋亡诱导细胞死亡。 DDHR的显着特征是其内部荧光，可以可视化标记的质膜和内部膜结构。

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《The Journal of Antibiotics: An International Journal》 |2011年第11期|共6页
作者
Stodulkova E; Kuzma M; Hench IB; Cerny J; Kralova J; Novak P; Chudickova M; Savic M; Djokic L; Vasiljevic B; Flieger M;
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正文语种 eng
中图分类药学;
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1. New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis. [J] . Stodulkova E, Kuzma M, Hench IB, The Journal of Antibiotics: An International Journal . 2011,第11期

机译：杜伦链霉菌的深层培养产生了新的多烯大环内酯类。
2. Postharvest disease control efficacy of the polyene macrolide lucensomycin produced by Streptomyces plumbeus strain CA5 against gray mold on grapes [J] . Kim Jeong Do, Kang Ji Eun, Kim Beom Seok Postharvest Biology and Technology . 2020,第期

机译：Postharvest疾病对葡萄灰霉素灰霉病生产的多烯Macroolide Lucensomycin的疗效
3. Identification of a Newly Isolated Streptomycete, Streptomyces sp SZK1, which Produces Polyene Macrolide Strevertenes [J] . Ninomiya Akinori, Kodani Shinya Journal of Pure & Applied Microbiology . 2013,第4期

机译：新分离的链霉菌，Streptomyces sp SZK1的鉴定，产生多烯大环内酯类强链
4. Submerged Culture Screening of Two Strains of Streptomyces sp. with High Keratinolytic Activity [C] . O. GARCIA-KIRCHNER, MA. E. BAUTISTA-RAMIREZ, M. SEGURA-GRANADOS Biotechnology for Fuels and Chemicals . 1998

机译：两种链霉菌菌株的水下培养筛选。角蛋白分解活性高
5. Genetic and biochemical studies of the biosynthesis and attachment of D-desosamine, the deoxy sugar component of macrolide antibiotics produced by Streptomyces venezuelae. [D] . Borisova, Svetlana Alekseyevna. 2004

机译：遗传和生化研究D-desosamine的生物合成和附着，D-desosamine是委内瑞斯链霉菌产生的大环内酯类抗生素的脱氧糖成分。
6. Correction for Han et al. Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63 [O] . Xing Han, Jiao Wang, Lianna Liu, 2021

机译：汉等人的校正关于链霉素Myco-93-63的鉴定和预测。
7. New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis [O] . Eva Stodůlková, Marek Kuzma, Ivana Bratic Hench, 2011

机译：新的Polyene Macroolide家族，由Streptomyces Durmitorensis淹没培养生产

New polyene macrolide family produced by submerged culture of Streptomyces durmitorensis.

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