KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603

KaiH.; YamashitaM.; TakaseS.; HashimotoM.; MuramatsuH.; NakamuraI.; YoshikawaK.; EzakiM.; NittaK.; WatanabeM.; InamuraN.; FujieA.

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KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603

机译：KB425796-A，一种由Paenibacillus sp。生产的新型抗真菌抗生素。 530603

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The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C79 H115 N19 O18. KB425796-A (1) showed antifungal activities against Aspergillus fumigatus and the micafungin-resistant infectious fungi Trichosporon asahii, Rhizopus oryzae, Pseudallescheria boydii and Cryptococcus neoformans.

机译：从细菌菌株530603的发酵液中分离了新型抗真菌大环脂肽内酯KB425796-A（1），该细菌菌株根据形态和生理特征以及16S rRNA序列被鉴定为新的Paenibacillus物种。通过溶剂萃取，HP-20和ODS-B柱色谱法并冻干分离KB425796-A（1），为白色粉末，并确定其分子式为C79 H115 N19 O18。 KB425796-A（1）显示了对烟曲霉和耐米卡芬净的传染性真菌特氏梭菌，米根霉，波氏假单胞菌和新隐球菌的抗真菌活性。

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《The Journal of Antibiotics: An International Journal》 |2013年第8期|共7页
作者
KaiH.; YamashitaM.; TakaseS.; HashimotoM.; MuramatsuH.; NakamuraI.; YoshikawaK.; EzakiM.; NittaK.; WatanabeM.; InamuraN.; FujieA.;
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正文语种 eng
中图分类药学;
关键词
Antifungal; Fermentation; Isolation; KB425796-A; Paenibacillus sp;

机译：抗真菌;发酵;分离;KB425796-A;芽孢杆菌;

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1. KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603 [J] . KaiH., YamashitaM., TakaseS., The Journal of Antibiotics: An International Journal . 2013,第8期

机译：KB425796-A，一种由Paenibacillus sp。生产的新型抗真菌抗生素。 530603
2. Paenibacillus polymyxa produces fusaricidin-type antifungal antibiotics active against Leptosphaeria maculans, the causative agent of blackleg disease of canola [J] . Beatty PH, Jensen SE Canadian journal of microbiology . 2002,第2期

机译：多粘芽孢杆菌可生产出针对沙门氏菌黑脚病病原体的镰刀菌黄斑病菌有效的镰刀菌素型抗真菌抗生素
3. Paenibacillus profundus sp. nov., a deep sediment bacterium that produces isocoumarin and peptide antibiotics [J] . RomanenkoL.A., TanakaN., SvetashevV.I., Archives of microbiology . 2013,第4期

机译：深刻芽孢杆菌nov。，一种产生异香豆素和肽类抗生素的深层沉积细菌
4. Antifungal Agent Produced by Rhizosphere Moulds from Lycopersicon esculentum (Mill) Against Fusarium oxysporum f. sp. lycopersici. [C] . Riajeng Kristiana, Suciatmih, Wibowo Mangunwardoyo International Symposium on Current Progress in Mathematics and Sciences . 2016

机译：由来自Lycopersicon Esculentum（Mill）的根际模具产生的抗真菌剂对抗Fusarium oxysporum f。 sp。 Lycopersici。
5. Investigations of an antifungal antibiotic produced by an environmental isolate of Paenibacillus polymyxa. [D] . Beatty, Perrin Hudson. 2000

机译：对多粘芽孢杆菌环境分离物产生的抗真菌抗生素的研究。
6. Draft Genome Sequence of Paenibacillus sp. Strain OSY-SE a Bacterium Producing the Novel Broad-Spectrum Lipopeptide Antibiotic Paenibacterin [O] . En Huang, Yaoqi Guo, Ahmed E. Yousef 2012

机译：Paenibacillus sp。的基因组序列草图。 OSY-SE菌株一种细菌可产生新型广谱脂肽抗生素药
7. Paenibacillus siamensis sp. nov., Paenibacillus septentrionalis sp. nov. and Paenibacillus montaniterrae sp. nov., xylanase-producing bacteria from Thai soils [O] . S. Khianngam, S. Tanasupawat, J.-S. Lee, 2009

机译：Paenibacillus siamensis sp。 11月。，Paenibacillus septentrionalis sp。 11月。和Paenibacillus montaniterrae sp。 11月。，泰国土壤的木聚糖酶产生细菌

KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603

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