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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Ribosomally synthesized peptides from natural sources
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Ribosomally synthesized peptides from natural sources

机译：天然来源的核糖体合成肽

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There are many antibiotic-resistant microbial pathogens that have emerged in recent years causing normal infections to become harder and sometimes impossible to treat. The major mechanisms of acquired resistance are the ability of the microorganisms to destroy or modify the drug, alter the drug target, reduce uptake or increase efflux of the drug and replace the metabolic step targeted by the drug. However, in recent years, resistant strains have been reported from almost every environment. New antimicrobial compounds are of major importance because of the growing problem of bacterial resistance, and antimicrobial peptides have been gaining a lot of interest. Their mechanism of action, however, is often obscure. Antimicrobial peptides are widespread and have a major role in innate immunity. An increasing number of peptides capable of inhibiting microbial growth are being reviewed here. In this article, we consider the possible use of antimicrobial peptides against pathogens.
机译：近年来出现了许多对抗生素产生抗药性的微生物病原体，导致正常的感染变得更加困难，有时甚至无法治疗。获得性抗药性的主要机制是微生物破坏或修饰药物，改变药物靶标，减少药物的吸收或增加药物外排以及替代药物靶向的代谢步骤的能力。但是，近年来，几乎所有环境都报告了耐药菌株。由于越来越多的细菌抗药性问题，新的抗菌化合物具有重要意义，抗菌肽已引起了广泛的关注。然而，它们的作用机理通常是晦涩的。抗菌肽广泛存在，并在先天免疫中起主要作用。在此综述了越来越多的能够抑制微生物生长的肽。在本文中，我们考虑了针对病原体的抗菌肽的可能用途。

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