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首页> 外文期刊>Chemistry: A European journal >Ribosomally synthesized and post-translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis
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Ribosomally synthesized and post-translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis

机译：核糖体合成和翻译后修饰的肽天然产物：前导肽和核心肽在生物合成过程中的作用的新见解

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Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with a high degree of structural diversity and a wide variety of bioactivities. Understanding the biosynthetic machinery of these RiPPs will benefit the discovery and development of new molecules with potential pharmaceutical applications. In this Concept article, we discuss the features of the biosynthetic pathways to different RiPP classes, and propose mechanisms regarding recognition of the precursor peptide by the post-translational modification enzymes. We propose that the leader peptides function as allosteric regulators that bind the active form of the biosynthetic enzymes in a conformational selection process. We also speculate how enzymes that generate polycyclic products of defined topologies may have been selected for during evolution.
机译：核糖体合成和翻译后修饰的肽（RiPPs）是一类主要的天然产物，具有高度的结构多样性和广泛的生物活性。了解这些RiPP的生物合成机制将有益于发现和开发具有潜在药物应用的新分子。在此概念文章中，我们讨论了通往不同RiPP类的生物合成途径的特征，并提出了有关通过翻译后修饰酶识别前体肽的机制。我们提出，前导肽作为构象调节剂，在构象选择过程中结合生物合成酶的活性形式。我们还推测如何在进化过程中选择产生定义拓扑的多环产物的酶。

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