Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2

ShaabanK.A.; SinghS.; ElshahawiS.I.; WangX.; PonomarevaL.V.; SunkaraM.; CopleyG.C.; HowerJ.C.; MorrisA.J.; KharelM.K.; ThorsonJ.S.

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Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2

机译：Venturicidin C，由链霉菌属的一种新的20元大环内酯。 TS-2-2

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Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenylnocardamine, ferrioxamine E, adenosine, riboflavin, cyclo(D)-trans-4-OH-Pro-(D)-Phe, cyclo(D)-Pro-(D)-Phe and N-(2-phenylethyl)- acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR spectroscopy and HR-MS data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell line but all displayed potent antifungal activity.

机译：从阿巴拉契亚细菌菌株Streptomyces sp。的粗提物中分离出Venturicidin C（1），一种新的20元大环内酯以及已知的venturicidins A（2）和B（3）。 TS-2-2。另外，还有九种其他已知化合物，即去甲酚胺，去羟基去甲酚胺，去甲烯基去甲酚胺，亚铁胺E，腺苷，核黄素，环（D）-反式-4-OH-Pro-（D）-Phe，环（D）-Pro-（D）-还分离并鉴定了Phe和N-（2-苯乙基）-乙酰胺。通过核磁共振波谱和HR-MS数据的累积分析，阐明了新的大环内酯1的结构。本报告中还首次提供了已知文丘里汀A（2）和B（3）的完整NMR分配。 Venturicidins A-C不会抑制A549肺癌细胞系的增殖，但都显示出有效的抗真菌活性。

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《The Journal of Antibiotics: An International Journal》 |2014年第3期|共8页
作者
ShaabanK.A.; SinghS.; ElshahawiS.I.; WangX.; PonomarevaL.V.; SunkaraM.; CopleyG.C.; HowerJ.C.; MorrisA.J.; KharelM.K.; ThorsonJ.S.;
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正文语种 eng
中图分类药学;
关键词
Apoptolidin; Microbial; Natural products; Secondary metabolites; Streptomyces;

机译：载脂蛋白;微生物;天然产物;次生代谢产物;链霉菌;

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1. Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2 [J] . ShaabanK.A., SinghS., ElshahawiS.I., The Journal of Antibiotics: An International Journal . 2014,第3期

机译：Venturicidin C，由链霉菌属的一种新的20元大环内酯。 TS-2-2
2. Macrolides of the bafilomycin family produced by Streptomyces sp. CS [J] . LiJ., LuC., ShenY. The Journal of Antibiotics: An International Journal . 2010,第10期

机译：链霉菌属产生的巴氟霉素家族的大环内酯类。 CS
3. Fermentation, isolation, purification and biological activity of SJA-95, a heptaene polyene macrolide antibiotic produced by the Streptomyces sp. strain S24. [J] . Naik SR, Desai SK, Nanda RK, Arzneimittel-Forschung: =Drug Research . 2007,第3期

机译：链霉菌属菌产生的七烯多烯大环内酯类抗生素SJA-95的发酵，分离，纯化和生物学活性。菌株S24。
4. Inhibition effects on Escherichia coli and Staphylococcus aureus of purple pigment produced by Streptomyces sp. Dagang-2 [C] . Liu HaiJun, Zhu MiJia, Yuan ZhiMin International Conference on Energy and Environmental Protection . 2014

机译：用链霉菌Sp产生的紫色颜料的大肠杆菌和金黄色葡萄球菌的抑制作用。大港-2.
5. Genetic and biochemical studies of the biosynthesis and attachment of D-desosamine, the deoxy sugar component of macrolide antibiotics produced by Streptomyces venezuelae. [D] . Borisova, Svetlana Alekseyevna. 2004

机译：遗传和生化研究D-desosamine的生物合成和附着，D-desosamine是委内瑞斯链霉菌产生的大环内酯类抗生素的脱氧糖成分。
6. Venturicidin C A New 20-Membered Macrolide Produced by Streptomyces sp. TS-2-2 [O] . Khaled A. Shaaban, Shanteri Singh, Sherif I. Elshahawi, -1

机译：Venturicidin C链霉菌属新产生的20元大环内酯。 TS-2-2
7. Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2 [O] . Khaled A Shaaban, Shanteri Singh, Sherif I Elshahawi, 2013

机译：文氏菌蛋白C，由Streptomyces SP产生的新的20元大环苷。 TS-2-2

Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2

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