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首页> 外文期刊>The Journal of Antibiotics: An International Journal >New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925
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New rubrolides from the marine-derived fungus Aspergillus terreus OUCMDZ-1925

机译：源自海洋真菌的曲霉曲霉OUCMDZ-1925

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摘要

Two new rubrolides, rubrolides R (1) and S (2), were isolated from the fermentation broth of the marine-derived fungus Aspergillus terreus OUCMDZ-1925. Their structures were elucidated on the basis of spectroscopic analysis and X-ray single crystal diffraction. Compound 1 showed comparable or superior antioxidation against 2,2′-azino-di(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals to those of trolox and ascorbic acid with an IC 50 value of 1.33 mM. Compound 2 showed comparable or superior anti-influenza A (H1N1) virus activity to that of ribavirin with an IC 50 value of 87.1 μM. Both compounds 1 and 2 showed weak cytotoxicity against the K562 cell line with IC 50 values of 12.8 and 10.9 μM, respectively.
机译：从海洋来源的真菌曲霉曲霉OUCMDZ-1925的发酵液中分离出两种新的rubrolide，即rubrolides R（1）和S（2）。在光谱分析和X射线单晶衍射的基础上阐明了它们的结构。化合物1对2,2'-叠氮基-二（3-乙基苯并噻唑啉-6-磺酸）（ABTS）自由基的表现与trolox和抗坏血酸相当或更高，IC 50值为1.33 mM。化合物2显示出与病毒唑相当或更好的抗A型流感病毒（H1N1）活性，IC 50值为87.1μM。化合物1和2均显示出对K562细胞系的弱细胞毒性，IC 50值分别为12.8和10.9μM。

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