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首页> 外文期刊>The Journal of Antibiotics: An International Journal >In vitro activity of fosfomycin in combination with linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus
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In vitro activity of fosfomycin in combination with linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus

机译：磷霉素与利奈唑胺联用对耐甲氧西林金黄色葡萄球菌临床分离株的体外活性

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摘要

The objective of this paper was to investigate the in vitro effects of fosfomycin combined with linezolid against methicillin-resistant Staphylococcus aureus (MRSA). A total of 102 MRSA isolates isolated from clinical specimens of human infections from three hospitals in China were studied. The microdilution checkerboard method was used to determine whether combinations act synergistically against these isolates. The susceptibility results for fosfomycin and linezolid were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. Synergy and indifference were defined as a fractional inhibitory concentration index of ≤0.5 and >0.5 but ≤4, respectively. The combination of fosfomycin and linezolid demonstrated the following interactions: 98.04% (100/102) synergism; 1.96% (2/102) indifference; no antagonism was seen. Thus, the combination between fosfomycin and linezolid shows synergism for most of the MRSA isolates tested in this study. If these findings are confirmed in further in vitro or in vivo studies, the above combination could be tested clinically for difficulty to treat MRSA infections, particularly those warranting prolonged oral therapy.
机译：本文的目的是研究磷霉素联合利奈唑胺对耐甲氧西林的金黄色葡萄球菌（MRSA）的体外作用。从中国三家医院的人类感染临床标本中分离出的102株MRSA分离株进行了研究。微稀释棋盘法用于确定组合是否对这些分离株具有协同作用。磷霉素和利奈唑胺的药敏结果根据临床和实验室标准协会的指南进行了解释。协同作用和冷漠分别定义为分数抑制浓度指数≤0.5和> 0.5但≤4。磷霉素和利奈唑胺的组合表现出以下相互作用：98.04％（100/102）协同作用;漠不关心1.96％（2/102）;没有看到对抗。因此，磷霉素和利奈唑胺之间的组合对本研究中测试的大多数MRSA分离株显示出协同作用。如果这些发现在进一步的体外或体内研究中得到证实，则可以对上述组合进行临床测试以治疗MRSA感染，特别是那些需要长期口服治疗的感染。

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