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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains
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Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains

机译：通过将Talaromyces siamensis FKA-61与多种真菌菌株共同培养，诱导产生BE-31405

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摘要

While isolating fungal strains from soil samples, two strains, Talaromyces siamensis FKA-61 and Phomopsis sp. FKA-62, were found to produce a black pigment near the boundary with an adjoining colony on agar plates. Moreover, strain FKA-61 inhibited the growth of strain FKA-62. Co-culture of T. siamensis FKA-61 with Phomopsis sp. FKA-62 resulted in the production of an antifungal agent, BE-31405, which proved active against Phomopsis sp. FKA-62. We screened for fungal genera that have the ability to induce production of antifungal BE-31405. Surprisingly, production of BE-31405 was induced only by co-culturing T. siamensis FKA-61 with a variety of BE-31405-sensitive fungal strains but never with BE-31405-insensitive strains. This is the first report of the induced production of a specific antibiotic active against antibiotic-sensitive fungal strains by co-culturing with them.
机译：从土壤样品中分离出真菌菌株时，有两种菌株：Talaromyces siamensis FKA-61和Phomopsis sp。发现FKA-62在琼脂平板上的边界附近产生黑色颜料，并带有邻接菌落。此外，菌株FKA-61抑制了菌株FKA-62的生长。中华锥虫FKA-61与拟南芥（Phomopsis sp。）的共培养FKA-62导致了抗真菌药BE-31405的产生，该药被证明具有抗Phomopsis sp。的活性。 FKA-62。我们筛选了具有诱导抗真菌BE-31405产生能力的真菌属。出人意料的是，仅通过与多种对BE-31405敏感的真菌菌株共培养暹罗镰刀菌FKA-61，而从未与对BE-31405不敏感的菌株共培养来诱导BE-31405的产生。这是关于通过与它们共同培养而诱导产生的对抗生素敏感真菌菌株具有活性的特定抗生素的首次报道。

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