LYMPHOSTIN (LK6-A), A NOVEL IMMUNOSUPPRESSANT FROM STREPTOMYCES SP. KY11783 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

Nagata H.; Aotani Y.; Ando K.; Yoshida M.; Takahashi I. Tamaoki T.; Ochiai K.

首页> 外文期刊>The Journal of Antibiotics: An International Journal >LYMPHOSTIN (LK6-A), A NOVEL IMMUNOSUPPRESSANT FROM STREPTOMYCES SP. KY11783 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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LYMPHOSTIN (LK6-A), A NOVEL IMMUNOSUPPRESSANT FROM STREPTOMYCES SP. KY11783 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

机译：淋巴素（LK6-A），一种来自链霉菌SP的新型免疫抑制剂。 KY11783-生产生物，发酵，分离和生物活性的分类法

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In the course of screening for inhibitors of the lymphocyte kinase, Lck (p56(lck)), aiming at novel immunosuppressants, we isolated a novel alkaloid, lymphostin (LK6-A), from the culture broth of Streptomyces sp. KY11783. Lymphostin was produced in a fermentation medium supplemented with a highly porous polymer resin, which prevented the degradation of this compound in the culture broth. Lymphostin inhibited the kinase activity of Lck with an IC50 value of 0.05 mu M, and exhibited potent inhibitory activity against the mixed lymphocyte reaction (MLR) with an IC50 value of 0.009 mu M. [References: 25]

机译：在筛选针对新型免疫抑制剂的淋巴细胞激酶Lck（p56（lck））抑制剂的过程中，我们从链霉菌属菌种的培养液中分离了新型生物碱，淋巴抑制素（LK6-A）。 KY11783。在补充了高度多孔的聚合物树脂的发酵培养基中产生了Lymphostin，这可防止该化合物在培养液中降解。淋巴抑制素以0.05μM的IC50值抑制Lck的激酶活性，并以0.005μM的IC50值表现出对混合淋巴细胞反应（MLR）的有效抑制活性。[参考：25]

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《The Journal of Antibiotics: An International Journal》 |1997年第7期|共6页
作者
Nagata H.; Aotani Y.; Ando K.; Yoshida M.; Takahashi I. Tamaoki T.; Ochiai K.;
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正文语种 eng
中图分类药学;药品;
关键词
Mice lacking p56(lck); Tyrosine kinase; Thymocyte development; T-cells; Fk506; Rats; Involvement; Inhibitors; Analogs;

机译：缺乏p56（lck）的小鼠;酪氨酸激酶;胸腺细胞发育;T细胞;Fk506;大鼠;参与;抑制剂;类似物;

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1. LYMPHOSTIN (LK6-A), A NOVEL IMMUNOSUPPRESSANT FROM STREPTOMYCES SP. KY11783 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES [J] . Nagata H., Aotani Y., Ando K., The Journal of Antibiotics: An International Journal . 1997,第7期

机译：淋巴素（LK6-A），一种来自链霉菌SP的新型免疫抑制剂。 KY11783-生产生物，发酵，分离和生物活性的分类法
2. Radamycin, a Novel Thiopeptide Produced by Streptomyces sp. RSP9 I. Taxonomy, Fermentation, Isolation and Biological Activities [J] . Gloria Gonzalez Holgado, Julian Castro Rodriguez, Librada M.Canedo Hernandez, The Journal of Antibiotics: An International Journal . 2002,第4期

机译：Radamycin，一种由链霉菌属产生的新型硫肽。 RSP9 I.分类学，发酵，分离和生物活动
3. Epostatin, new inhibitor of dipeptidyl peptidase II, produced by Streptomyces sp. MJ995-OF5 - I. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties and biological properties [J] . Akiyama T., Kojima F., Kinoshita N., The Journal of Antibiotics: An International Journal . 1998,第3期

机译：Epostatin，链霉菌属sp。生产的二肽基肽酶II的新抑制剂。 MJ995-OF5-I.生产菌株的分类，发酵，分离，理化特性和生物学特性
4. Isolation, identification and activity of insecticidal components from Streptomyces sp. 4138 [C] . B R Lin, X M Pu, H F Shen, International Plant Protection Congress . 2007

机译：杀虫组分的分离，鉴定和活性来自链霉菌SP的杀虫组分。 4138.
5. ISOLATION AND CHARACTERIZATION OF GENES FROM BETA-LACTAM ANTIBIOTIC PRODUCING ORGANISMS (PENICILLIUM CHRYSOGENUM, RIBOSOMAL-RNA, CEPHALOSPORIUM ACREMONIUM, ISOPENICILLIN N SYNTHETASE). [D] . CARR, LUCINDA GAYLE. 1986

机译：从β-内酰胺类抗生素生产基因（青霉菌，核糖体RNA，头孢杆菌，异戊二烯N合成酶）中分离和鉴定基因。
6. Correction: Singh, M.P., et al. Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities [O] . Maya P. Singh, Jeffrey E. Janso, Sean F. Brady 2018

机译：校正：Singh，M.P.等。 Cytospora sp。生产的Cytoskyrins和Cytosporones。 CR200：分类学，发酵和生物活动
7. Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. I. Taxonomy, fermentation, isolation and biological activities [O] . González Holgado Gloria, Castro Rodríguez, Julian, Díaz, Margarita, 2013

机译：Radamycin，一种由链霉菌属产生的新型硫肽。 RSP9。 I.分类学，发酵，分离和生物活动

LYMPHOSTIN (LK6-A), A NOVEL IMMUNOSUPPRESSANT FROM STREPTOMYCES SP. KY11783 - TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITIES

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