MULTICOMPONENT SYNTHESIS OF THE MEDICINALLY IMPORTANT PYRROLO[2,3-d]PYRIMIDINE SCAFFOLD (MINIREVIEW)

R. Dasari; A. Kornienko

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MULTICOMPONENT SYNTHESIS OF THE MEDICINALLY IMPORTANT PYRROLO[2,3-d]PYRIMIDINE SCAFFOLD (MINIREVIEW)

机译：药物重要的吡咯并[2,3-d]嘧啶骨架的多组分合成（MINIREVIEW）

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Multicomponent reactions are emerging as a powerful tool in the synthesis of heterocyclic privileged medicinal scaffolds. This highlight describes a recently developed approach to the construction of the medicinally important pyrrolo[2,3-d]pyrimidine scaffold using a one-pot synthesis from commercially available starting materials via novel multicomponent reactions.

机译：多组分反应正在成为合成杂环特有药物支架的有力工具。本集锦描述了一种最近开发的方法，该方法使用一锅合成法通过新颖的多组分反应，从商业上可获得的原料构建具有医学重要性的吡咯并[2,3-d]嘧啶骨架。

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《Chemistry of heterocyclic compounds》 |2014年第2期|共6页
作者
R. Dasari; A. Kornienko;
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正文语种 eng
中图分类杂环化合物;
关键词
7-deazapurines; drug discovery; heterocycle; multicomponent reactions; privileged scaffold.;

机译：7-脱氮嘌呤;药物发现;杂环;多组分反应;特权支架。;

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1. MULTICOMPONENT SYNTHESIS OF THE MEDICINALLY IMPORTANT PYRROLO[2,3-d]PYRIMIDINE SCAFFOLD (MINIREVIEW) [J] . R. Dasari, A. Kornienko Chemistry of heterocyclic compounds . 2014,第2期

机译：药物重要的吡咯并[2,3-d]嘧啶骨架的多组分合成（MINIREVIEW）
2. Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents [J] . Chaitanya G. Dave, Rina D. Shah Molecules . 2002,第7期

机译：三唑和四唑体系在吡咯并[2,3-d]嘧啶上的偶联反应：替他唑并[1,5-c]-吡咯并[3,2-e]-嘧啶和三唑并[1,5-c]吡咯并[[ 3,2-e]嘧啶类作为潜在的抗菌剂
3. Novel Synthesis,Properties,and NAD~+-NADH Type Redox Ability of l,3-Dimethylcyclohepta[4,5]pyrrolo[2,3-d]pyrimidine-2,4(1, H)-dionylium Ions Annulated with Additional Pyrrolo[2,3-d]pyrimidine-l,3(2,4H)-dione and Furan Analogue,and Their Hydride Adduc [J] . Shin-ichi Naya, Junya Nishimura, Makoto Nitta The Journal of Organic Chemistry . 2005,第24期

机译：1,3-二甲基环庚[4,5]吡咯并[2,3-d]嘧啶-2,4（1，H）-重氮鎓离子与其他吡咯并合的新型合成，性质和NAD〜+ -NADH型氧化还原能力[2,3-d]嘧啶-1,3（2,4H）-二酮和呋喃类似物及其氢化物
4. SYNTHESIS OF OCTAHYDRO-PYRROLO3,4-b-PIPIREDIN-2-ONES, OCTAHYDRO-PYRROLO3,4-bAZEPIN-2-ONES AND REACTIONS WITH THEM(Abstracts) [C] . Valery S Kochubey, Oleg M Shamaev, Oleg G Rodin European Symposium on Organic Chemistry . 2007

机译：八氢盐 - 吡咯的合成3,4-B - 哌啶-2-吡咯3,4-B偶氮二蛋白-2-β-2 - 与它们（摘要）
5. Synthesis of substituted pyrrolo[2,3-d]pyrimidines as microtubule-binding agents and HSP90 inhibitors [D] . Lin, Lu 2013

机译：取代吡咯并[2,3-d]嘧啶类化合物作为微管结合剂和HSP90抑制剂的合成
6. Annellation of Triazole and Tetrazole Systems onto Pyrrolo23-dpyrimidines: Synthesis of Tetrazolo15-c-pyrrolo32-e-pyrimidines and Triazolo15-cpyrrolo-32-epyrimidines as Potential Antibacterial Agents [O] . Chaitanya G. Dave, Rina D. Shah 2002

机译：三唑和四唑体系在吡咯并23-d嘧啶上的退火反应：替他唑并15-c-吡咯并32-e-嘧啶和三唑并15-c吡咯并 32-e嘧啶类作为潜在的抗菌剂
7. Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents [O] . Rina D. Shah, Chaitanya G. Dave 2002

机译：将三唑和四唑体系连接到吡咯并[2,3-d]嘧啶上：四唑并[1,5-c] - 吡咯并[3,2-e] - 嘧啶和三唑并[1,5-c]吡咯并[]的合成3,2-e]嘧啶作为潜在的抗菌剂

MULTICOMPONENT SYNTHESIS OF THE MEDICINALLY IMPORTANT PYRROLO[2,3-d]PYRIMIDINE SCAFFOLD (MINIREVIEW)

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