Interaction of 5-(Morpholin-4-Yl)-2-(4-Phthal-Imidobutyl)- and 5-(Morpholin-4-Yl)-2-(5-Phthal-Imidopentyl)-1,3-Oxazole-4-Carbonitriles with Hydrazine Hydrate

Chumachenko S. A.; Shablykin O. V.; Brovarets V. S.

首页> 外文期刊>Chemistry of heterocyclic compounds >Interaction of 5-(Morpholin-4-Yl)-2-(4-Phthal-Imidobutyl)- and 5-(Morpholin-4-Yl)-2-(5-Phthal-Imidopentyl)-1,3-Oxazole-4-Carbonitriles with Hydrazine Hydrate

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Interaction of 5-(Morpholin-4-Yl)-2-(4-Phthal-Imidobutyl)- and 5-(Morpholin-4-Yl)-2-(5-Phthal-Imidopentyl)-1,3-Oxazole-4-Carbonitriles with Hydrazine Hydrate

机译：5-（Morpholin-4-Yl）-2-（4-Phthal-Imidobutyl）-和5-（Morpholin-4-Yl）-2-（5-Phthal-Imidopentyl）-1,3-Oxazole-4的相互作用-水合肼与碳腈

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摘要

5-Morpholino-1,3-oxazole-4-carbonitriles bearing 4-phthalimidobutyl or 5-phthalimidopentyl substi-tuent at position 2 of the oxazole ring were synthesized. Upon reaction with hydrazine hydrate, 5-(morpholin-4-yl)-2-(4-phthalimidobutyl)-1,3-oxazole-4-carbonitrile formed the recyclization product (3-amino-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)(morpholin-4-yl)methanone, whereas for 5-(morpholin-4-yl)-2-(5-phthalimidopentyl)-1,3-oxazole-4-carbonitrile, the reaction stops at the stage of 2-(5-aminopentyl)-5-(morpholin-4-yl)-1,3-oxazole-4-carbonitrile after removal of the phthalimido protecting group.

机译：合成了在恶唑环的2位带有4-邻苯二甲酰亚胺基丁基或5-邻苯二甲酰亚胺基戊基的5-Morpholino-1,3-恶唑-4-腈。与水合肼反应后，5-（吗啉-4-基）-2-（4-邻苯二甲酰亚胺基丁基）-1,3-恶唑-4-腈形成再循环产物（3-氨基-5,6,7,8-四氢咪唑并[1,2-a]吡啶-2-基）（吗啉-4-基）甲酮，而对于5-（吗啉-4-基）-2-（5-邻苯二甲酰基戊基）-1,3-恶唑-4 -甲腈，除去邻苯二甲酰亚胺基保护基后，反应在2-（5-氨基戊基）-5-（吗啉-4-基）-1,3-恶唑-4-腈的阶段停止。

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来源
《Chemistry of heterocyclic compounds》 |2015年第12期|共4页
作者
Chumachenko S. A.; Shablykin O. V.; Brovarets V. S.;
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正文语种 eng
中图分类杂环化合物;
关键词
2-(5-aminopentyl)-5-(morpholin-4-yl)-1; 3-oxazole-4-carbonitrile; (3-amino-5; 6; 7; 8-tetrahydroimidazo1; 2-alphapyridin-2-yl)(morpholin-4-yl)methanone; heterocyclization; hydrazinolysis; recyclization;

机译：2-（5-氨基戊基）-5-（吗啉-4-基）-1;3-恶唑-4-腈;（3-氨基-5;6;7;8-四氢咪唑并[1;2-α]吡啶-2-基）（吗啉-4-基）甲酮;杂环化;肼解;再循环;

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1. Synthesis, Characterization, Spectroscopic Properties of 2-(4-Dimethylaminophenyl)-5-fluoro-6-(morpholin-4-yl)-1H-benzimidazole and its Interaction with Calf Thymus DNA [J] . Ling Tian TANG, Yi WANG, Xin Qi LIU, 中国化学快报（英文版） . 2005,第003期
2. Interaction of 5-(Morpholin-4-Yl)-2-(4-Phthal-Imidobutyl)- and 5-(Morpholin-4-Yl)-2-(5-Phthal-Imidopentyl)-1,3-Oxazole-4-Carbonitriles with Hydrazine Hydrate [J] . Chumachenko S. A., Shablykin O. V., Brovarets V. S. Chemistry of heterocyclic compounds . 2015,第12期

机译：5-（Morpholin-4-Yl）-2-（4-Phthal-Imidobutyl）-和5-（Morpholin-4-Yl）-2-（5-Phthal-Imidopentyl）-1,3-Oxazole-4的相互作用-水合肼与碳腈
3. Synthesis and antimicrobial activity of some 5-(2-(morpholin-4-yl)acetamido) and/or 5-(2-(4-substituted piperazin-1-yl)acetamido)-2-(p-substituted phenyl)benzoxazoles. [J] . Temiz Arpaci O, Ozdemir A, Yalcin I, Archiv der Pharmazie . 2005,第2a3期

机译：一些5-（2-（吗啉-4-基）乙酰胺基）和/或5-（2-（4-取代的哌嗪-1-基）乙酰胺基）-2-（对取代的苯基）苯并恶唑的合成及抑菌活性。
4. Crystal structure of 3,4-dimethyl 2-(tert-butylamino)-5-[2-oxo-4-(thiomorpholin-4-yl)-2H-chromen-3-yl]furan-3,4-dicarboxylate ethyl acetate hemisolvate [J] . Moriguchi T., Jalli V., Krishnamurthy S., Acta Crystallographica Section E: Crystallographic Communications . 2015,第12期

机译：3,4-二甲基2-（叔丁基氨基）-5- [2-氧-4-（硫吗啉-4-基）-2H-铬-3-基]呋喃-3,4-二羧酸乙酯的晶体结构半溶剂化物
5. Study on the Interaction of fluorescent probe 2-(2'-Chloro phenyl)-5-(2'- hydroxyl phenyl)1,3,4-oxadiazole with DNA [C] . Ding Mei, Lei Yingjie, Xu Fang, International Conference on Advanced Engineering Materials and Technology . 2011

机译：荧光探针2-（2'-氯苯基）-5-（2'-羟基苯基）1,3,4-二氧化氮与DNA的相互作用研究
6. Synthesis of analogs of 5-[2-(5-amidinobenzimidazoyl)]-2-(4-amidinophenyl)furan hydrochloride to test a DNA minor groove dimer binding model. [D] . Batista-Parra, Adalgisa. 2002

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7. (E)-1-(3-Nitrophenyl)-2-({5-(1E)-2-(3-nitrophenyl)hydrazin-1-ylidenemethyl-2-thienyl}methylidene)hydrazine [O] . Geraldo M. de Lima, William T. A. Harrison, Edward R. T. Tiekink, 2010

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8. Ethyl 1-[2-(morpholin-4-yl)ethyl]-2-[4-(morpholin-4-yl)phenyl]-1H-1,3-benzimidazole-5-carboxylate [O] . Yoon, Yeong Keng, Ali, Mohamed Ashraf, Ismail, Rusli, 2011

机译：1- [2-（吗啉-4-基）乙基] -2- [4-（吗啉-4-基）苯基] -1H-1,3-苯并咪唑-5-羧酸乙酯
9. Liquid Crystalline Polymers Containing Heterocycloalkane Mesogens. 4. Biphasic Side-Chain Liquid Crystalline Polysiloxanes Containing Trans 5-(n-Undecanyl)-2-(4-Methoxyphenyl)-1,3-Dioxane and Trans 2-(n-Decanyl)-5-(4-Methoxyphenyl [R] . Hsu, C. S., Percec, V. 1986

机译：含有杂环烷烃中间体的液晶聚合物。 4.含有反式5-（正十一烷基）-2-（4-甲氧基苯基）-1,3-二恶烷和反式2-（正十二烷基）-5-（4-甲氧基苯基）的双相侧链液晶聚硅氧烷

Interaction of 5-(Morpholin-4-Yl)-2-(4-Phthal-Imidobutyl)- and 5-(Morpholin-4-Yl)-2-(5-Phthal-Imidopentyl)-1,3-Oxazole-4-Carbonitriles with Hydrazine Hydrate

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