Syntheses Based on 4-Chloro-1-[3,5-di(trifluoromethyl)phenyl]-, 4-Chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, and 4-Chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazoles

I. Strakova; A. Strakovs; M. Petrova

首页> 外文期刊>Chemistry of heterocyclic compounds >Syntheses Based on 4-Chloro-1-[3,5-di(trifluoromethyl)phenyl]-, 4-Chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, and 4-Chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazoles

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Syntheses Based on 4-Chloro-1-[3,5-di(trifluoromethyl)phenyl]-, 4-Chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, and 4-Chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazoles

机译：基于4-氯-1- [3,5-二（三氟甲基）苯基]-，4-氯-1-（2,4-二氟苯基）-5-甲酰基-3-甲基-6,7-二氢吲唑的合成，和4-氯-5-甲酰基-3-甲基-1-（2-吡啶基）-6,7-二氢吲唑

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Vilsmeier formylation of 1-[3,5-di(trifluoromethyl)phenyl]- and 1-(2,4-difluorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles gave the corresponding 1-aryl-4-chloro-5-formyl-3-methyl-6,7-dihydroindazoles. Reaction of the latter with amidines, o-phenylenediamine, hydrazine, or hydroxylamine gave a series of 1-aryl-3-methyl-6,6-dihydroindazoles annelated at positions 4 and 5. The reaction of 4-chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazole with substituted anilines gave 5-arylaminomethylene-4-oxo- or 5-arylaminomethylene-4-arylimino-3-methyl-1-(2-pyridyl)-4,5,6,7-tetrahydroindazoles depending on the molar ratio of reagents and the nucleophilicity of the amines.

机译：1- [3,5-二（三氟甲基）苯基]-和1-（2,4-二氟苯基）-3-甲基-4-氧代-4,5,6,7-四氢吲唑的Vilsmeier甲酰化反应得到相应的1-芳基-4-氯-5-甲酰基-3-甲基-6,7-二氢吲唑。后者与am，邻苯二胺，肼或羟胺反应，得到一系列在位置4和5退火的1-芳基-3-甲基-6,6-二氢吲唑。4-氯-5-甲酰基- 3-甲基-1-（2-吡啶基）-6,7-二氢吲唑与取代的苯胺得到5-芳基氨基亚甲基-4-氧-或5-芳基氨基亚甲基-4-芳基-3-甲基-1-（2-吡啶基）- 4,5,6,7-四氢吲唑取决于试剂的摩尔比和胺的亲核性。

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《Chemistry of heterocyclic compounds》 |2005年第5期|共10页
作者
I. Strakova; A. Strakovs; M. Petrova;
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中图分类杂环化合物;
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β-arylaminovinyl ketones; β-arylaminovinylarylimines; 4; 5-dihydro-7H-benzobindazolo-4; 5-ediazepines; 4; 5-dihydro-1H-pyrazolo3; 4-eindazoles; 3; 8-substituted 4; 5-dihydropyrazolo5; 4-h-quinazolines; β-chlorovinylaldehydes;

机译：β-芳基氨基乙烯基酮;β-芳基氨基乙烯基芳烃;4;5-二氢-7H-苯并[b]吲唑并-[4;5-e]二氮杂;4;5-二氢-1H-吡唑并[3;4-e]吲唑;3;8-取代的4;5-二氢吡唑并[5;4-h]-喹唑啉;β-氯乙烯基醛;

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1. Syntheses Based on 4-Chloro-1-[3,5-di(trifluoromethyl)phenyl]-, 4-Chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, and 4-Chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazoles [J] . I. Strakova, A. Strakovs, M. Petrova Chemistry of heterocyclic compounds . 2005,第5期

机译：基于4-氯-1- [3,5-二（三氟甲基）苯基]-，4-氯-1-（2,4-二氟苯基）-5-甲酰基-3-甲基-6,7-二氢吲唑的合成，和4-氯-5-甲酰基-3-甲基-1-（2-吡啶基）-6,7-二氢吲唑
2. Spin crossover in iron(II) complexes of 3,5-di(2-pyridyl)-l,2,4-triazoles and 3,5-di(2-pyridyl)-1,2,4-triazolates [J] . Jonathan A. Kitchen, Sally Brooker Coordination chemistry reviews . 2008,第18a20期

机译：3,5-二（2-吡啶基）-1,2,4-三唑和3,5-二（2-吡啶基）-1,2,4-三唑化物的铁（II）配合物中的自旋交叉
3. Synthesis of 2-alky1-5-phenylaminomethyl-2,4-dihydro-3H-[1,2,4] triazol-3-ones based on 2-alkyl-6-phenyl-6,7-dihydro-3H-imidazo[5,1-c][1,2,4]triazole-3,5(2H)-diones [J] . Komogortsev A. N., Lichitskii B. V., Krylov K. S., Russian Chemical Bulletin . 2014,第7期

机译：基于2-烷基-6-苯基-6,7-二氢-3H-咪唑基的2-烷基1-5-苯基氨基甲基-2,4-二氢-3H- [1,2,4]三唑-3-酮的合成[ 5,1-c] [1,2,4]三唑-3,5（2H）-二酮
4. 1-[3,5-Bis(trifluoromethyl)phenyl]-3-(2-pyridyl)thiourea [O] . Danqian Xu, Shuping Luo, Aibao Xia, 2008

机译：1- [3,5-双（三氟甲基）苯基] -3-（2-吡啶基）硫脲

Syntheses Based on 4-Chloro-1-[3,5-di(trifluoromethyl)phenyl]-, 4-Chloro-1-(2,4-difluorophenyl)-5-formyl-3-methyl-6,7-dihydroindazoles, and 4-Chloro-5-formyl-3-methyl-1-(2-pyridyl)-6,7-dihydroindazoles

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